Chemokine receptor expression defines heterogeneity in the earliest thymic migrants
Chemokine receptor expression defines heterogeneity in the earliest thymic migrants
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DOI：
10.1002/eji.200737212
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发表时间：
2007-08-01
影响因子：
5.4
通讯作者：
Anderson, Graham
中科院分区：
文献类型：
--
作者：
Jenkinson, William E.;Rossi, Simona W.;Anderson, Graham
趋化因子信号转导与造血前体在胎儿胸腺的定向定殖有关。然而，负责指导最早期胸腺移民的胸腺定植的趋化因子受体的表达模式仍然未知。基于趋化因子受体表达，我们已经确定了最早期胸腺种子细胞的异质性。通过分析第一波的祖细胞在E12的妊娠期定殖胸腺，我们表明，多种趋化因子受体表达的T淋巴前体存在于胸腺周围间充质，而表达的趋化因子配体仅限于CCL 21，CCL 25和CXCL 12，这是位于不同的上皮和间充质室的胸腺/甲状旁腺原基。总的来说，这些结果确定了多个群体的T-淋巴前体定殖胎儿胸腺，并提供了几个潜在的途径介导的前体迁移到胚胎胸腺的证据。
Chemokine signaling has been implicated in directing colonization of the fetal thymus by hematopoietic precursors. However, the patterns of expression of the chemokine receptors responsible for directing thymic colonization by the earliest thymic migrants remain unknown. We have identified heterogeneity within the earliest thymus seeding cells based on chemokine receptor expression. By analyzing the first wave of progenitors to colonize the thymus at E12 of gestation, we show that multiple chemokine receptors are expressed by T-lymphoid precursors present within perithymic mesenchyme, while expression of chemokine ligands is limited to CCL21, CCL25 and CXCL12, which are located in distinct epithelial and mesenchymal compartments of the thymic/parathyroid anlagen. Collectively, these results identify multiple populations of T-lymphoid precursors colonizing the fetal thymus and provide evidence for several potential pathways mediating migration of precursors into the embryonic thymus.