Adaptive Evolution of Gene Expression in Drosophila.
Adaptive Evolution of Gene Expression in Drosophila.
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DOI：
10.1016/j.celrep.2017.07.033
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发表时间：
2017-08
期刊：
影响因子：
8.8
通讯作者：
Armita Nourmohammad;Joachim Rambeau;Torsten Held;Viera Kováčová;J. Berg;M. Lässig
中科院分区：
文献类型：
--
作者：
Armita Nourmohammad;Joachim Rambeau;Torsten Held;Viera Kováčová;J. Berg;M. Lässig
基因表达水平是将基因型与分子功能和适应性联系起来的重要数量性状。在果蝇中，群体遗传学研究揭示了基因组水平上的实质性适应性进化，但基因表达的进化模式仍然存在争议。在这里，我们提出的证据表明，适应主导了果蝇基因表达水平的进化。我们发现，在七个果蝇物种中观察到的表达差异中有 64% 是由方向选择驱动的适应性变化。我们的结果来自相关物种家族的基因表达差异的时间分辨数据，使用概率推理方法进行基因特异性选择。适应性基因表达在特定功能类别中更强，包括调节、感官知觉、性行为和形态。此外，我们还发现了一大批具有性别特异性表达适应的基因，这些基因主要发生在男性中。我们的分析开辟了一条途径，可以独立于分子数量性状的遗传基础来绘制系统范围的选择。
Gene expression levels are important quantitative traits that link genotypes to molecular functions and fitness. InDrosophila, population-genetic studies have revealed substantial adaptive evolution at the genomic level, but the evolutionary modes of gene expression remain controversial. Here, we present evidence that adaptation dominates the evolution of gene expression levels in flies. We show that 64% of the observed expression divergence across sevenDrosophilaspecies are adaptive changes driven by directional selection. Our results are derived from time-resolved data of gene expression divergence across a family of related species, using a probabilistic inference method for gene-specific selection. Adaptive gene expression is stronger in specific functional classes, including regulation, sensory perception, sexual behavior, and morphology. Moreover, we identify a large group of genes with sex-specific adaptation of expression, which predominantly occurs in males. Our analysis opens an avenue to map system-wide selection on molecular quantitative traits independently of their genetic basis.