Chromosomal analyses of 52 cases of follicular lymphoma with t(14;18), including blastic/blastoid variant
Chromosomal analyses of 52 cases of follicular lymphoma with t(14;18), including blastic/blastoid variant
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DOI：
10.1016/s0165-4608(00)00383-6
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发表时间：
2001-04-01
影响因子：
--
通讯作者：
Al-Katib, A
中科院分区：
文献类型：
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作者：
Mohamed, AN;Palutke, M;Al-Katib, A
我们确定了52例滤泡性淋巴瘤（FL）与t（14;18）（q32;q21）。在组织学上，根据淋巴瘤的细胞组成和生长模式将其分为六组。染色体分析显示，除一例外，所有病例均有额外的继发性染色体异常。最常见的数目畸变是7号染色体（38%）、X（36%）、5号染色体（15%）、12号染色体（15%）、18/der（18）t（14;18）（25%）和21号染色体（15%）的增加。在19例（36%）累及双臂的肿瘤中观察到1号染色体结构异常，断裂点聚集在1 p36。其他结构异常包括6 q、10 q和13 q的部分缺失。4例断点位于8 q24。染色体畸变与滤泡性淋巴瘤的形态学亚型有关。7号染色体的获得似乎与滤泡性大细胞淋巴瘤相关。具有侵袭性组织学特征的滤泡性淋巴瘤中5、12和13 q-三体的发生率高于低级别淋巴瘤。此外，随着年级的升高，核型复杂程度和多倍性程度也随之增高。t（14;18）淋巴瘤中最有价值的细胞遗传学标志物是那些涉及8 q24的标志物，该标志物仅在母细胞/母细胞样变体FL中发现。因此，与滤泡性淋巴瘤组织学模式相关的染色体分析可以提供额外的信息预测肿瘤演变和向更高级别恶性肿瘤的转化。(C)2001 Elsevier Science Inc. All rights reserved.
We have identified 52 patients of follicular lymphoma (FL) with t(14;18)(q32;q21). Histologically, the lymphomas were placed into six groups according to their cellular composition and growth pattern. Chromosome analysis revealed that all cases but one had additional secondary chromosomal abnormalities. The most frequent numerical aberrations were gains of chromosomes 7 (38%), X (36%), 5 (15%), 12 (15%), 18/der(18)t(14;18) (25%), and 21 (15%). Structural abnormalities of chromosome 1 were seen in 19 tumors (36%) affecting both arms with breakpoints clustered at 1p36. Other structural abnormalities included partial deletions of 6q, 10q, and 13q. Breakpoint at 8q24 was seen in four cases. The chromosome aberrations were correlated with the morphological subtypes of follicular lymphoma. Gain of chromosome 7 appeared to be associated with follicular large cell lymphoma. The incidence of trisomy 5 and 12, and 13q- was higher in follicular lymphoma with aggressive histological features than in low-grade lymphoma. In addition, complexity of the karyotype and high degree of polyploidy increased with the grade. The most valuable cytogenetic markers in the t(14;18) lymphomas are those involving 8q24 which was found exclusively in the blastic/blastoid variant FL. Therefore, chromosome analysis in relation to histologic pattern of follicular lymphoma can provide additional information in predicting tumor evolution and transformation to a higher-grade malignancy. (C) 2001 Elsevier Science Inc. All rights reserved.