Interstitial fluid glucose time-lag correction for real-time continuous glucose monitoring
Interstitial fluid glucose time-lag correction for real-time continuous glucose monitoring
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DOI：
10.1016/j.bspc.2012.05.007
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发表时间：
2013-01-01
影响因子：
5.1
通讯作者：
Steil, Garry M.
中科院分区：
文献类型：
--
作者：
Keenan, D. Barry;Mastrototaro, John J.;Steil, Garry M.
皮下组织液和血浆葡萄糖之间的时间滞后降低了实时连续葡萄糖监测仪的准确性。然而，可以设计逆滤波器来校正时间滞后并衰减噪声，使得能够根据体液葡萄糖的连续测量来在真实的时间中重建血糖分布。我们设计并测试了一个维纳滤波器，使用一组20个传感器葡萄糖描记（类似于30小时）与1分钟的采样间隔。在加性高斯白色噪声（SNR = 40 dB）下，将10 +/- 2 min（平均值+/- SD）的延迟引入每个信号。该滤波器的性能进行了比较，传统的因果关系和非因果关系的七阶有限脉冲响应（FIR）滤波器。时间滞后引入了5.3 +/-2.7%的误差。在存在噪声的情况下，误差增加（至5.7 +/-2.6%），并且尝试用常规低通滤波去除噪声进一步增加了误差（至7.0 +/-3.5%）。相比之下，维纳滤波器在存在噪声的情况下将归因于时间延迟的误差降低了约50%（从5.7%降低到2.60 +/- 1.26%），并且在不存在噪声的情况下降低了约75%（从5.3%降低到1.3 +/- 1%）。引入时滞校正而不增加对噪声的敏感性可以增加CGM准确度。(C)2012爱思唯尔有限公司保留所有权利。
Time lag between subcutaneous interstitial fluid and plasma glucose decreases the accuracy of real-time continuous glucose monitors. However, inverse filters can be designed to correct time lag and attenuate noise enabling the blood-glucose profile to be reconstructed in real time from continuous measurements of the interstitial-fluid glucose. We designed and tested a Wiener filter using a set of 20 sensor-glucose tracings (similar to 30 h each) with a 1-min sample interval. Delays of 10 +/- 2 min (mean +/- SD) were introduced into each signal with additive Gaussian white noise (SNR = 40 dB). Performance of the filter was compared to conventional causal and non-causal seventh-order finite-impulse response (FIR) filters. Time lags introduced an error of 5.3 +/- 2.7%. The error increased in the presence of noise (to 5.7 +/- 2.6%) and attempts to remove the noise with conventional low-pass filtering increased the error still further (to 7.0 +/- 3.5%). In contrast, the Wiener filter decreased the error attributed to time delay by similar to 50% in the presence of noise (from 5.7% to 2.60 +/- 1.26%) and by similar to 75% in the absence of noise (5.3% to 1.3 +/- 1%). Introducing time-lag correction without increasing sensitivity to noise can increase CGM accuracy. (C) 2012 Elsevier Ltd. All rights reserved.