Effect of neonatally administered estrogen on development of male and female rats.
Effect of neonatally administered estrogen on development of male and female rats.
复制标题
新生儿给予雌激素对雄性和雌性大鼠发育的影响。
DOI：
10.1210/endo-87-2-435
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发表时间：
1970
期刊：
影响因子：
4.8
通讯作者：
A. Gerall
中科院分区：
文献类型：
--
作者：
Shelton E. Hendricks;A. Gerall
这项调查是，在某种程度上，一项研究的复制，该研究报告说，子宫内给予雌激素雄性化的遗传雌性大鼠的程度，它表现出射精反应。雄性和雌性大鼠在4日龄时注射100 μg苯甲酸雌二醇（EB）或油。与对照组相比，经尿道注射EB的雄性动物睾丸下降延迟，雄性性行为、体重和睾丸重量下降。组织学检查时，发现EB给药雄性动物的睾丸存在小管异常。而女性生殖器注射EB表现出更多的不完全和completecopulatory反应外源性雄激素在成熟时比对照组，没有表现出射精模式。EB给药雌性动物出现阴道开口早熟、阴道周期中断、卵巢无排卵和体重高于正常青春期后体重。（内分泌学87：435，1970
This investigation is, in part, a replication of a study which reported that neonatally administered estrogen masculinizes the genetic female rat to the extent that it exhibits ejaculatory responses. Male and female rats were injected when 4 days old with either 100 μg estradiol benzoate (EB) or oil. In comparison to controls, males neonatally injected with EB had delayed testicular descent and decreased male sexual behavior, body weight and testis weight. Upon histological examination, the testes of EB-treated males were found to have tubular abnormalities. While females injected neonatally with EB exhibited more incomplete and completecopulatory responses to exogenous androgen given at maturity than control subjects, none exhibited ejaculatory patterns. EBtreated females had precocious vaginal openings, disrupted vaginal cycles, anovulatory ovaries and heavier than normal postpuberal body weights.(Endocrinology 87:435,1970