Changes in Prevalence and Clinical Characteristics of Cervical Cancer in the People's Republic of China: A Study of 10,012 Cases From a Nationwide Working Group
Changes in Prevalence and Clinical Characteristics of Cervical Cancer in the People's Republic of China: A Study of 10,012 Cases From a Nationwide Working Group
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中华人民共和国宫颈癌患病率和临床特征的变化：全国工作组10,012例的研究
DOI：
10.1634/theoncologist.2013-0123
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发表时间：
2013-10-01
期刊：
影响因子：
5.8
通讯作者：
Ma, Ding
中科院分区：
文献类型：
--
作者：
Li, Shuang;Hu, Ting;Ma, Ding
目的.世界每年新发宫颈癌病例总数中约有三分之一发生在中华人民共和国。我们调查了中华人民共和国过去十年宫颈癌病例的患病率和临床特征。法2000年至2009年，全国各地区共纳入10，012例住院宫颈癌患者。分析了人口统计学和临床特征、治疗策略和结局。结果所有宫颈癌患者诊断时的平均年龄为44.7 ± 9.5岁，比中华人民共和国2000年之前报告的平均年龄小5-10岁。年龄分布显示16.0%的患者为45岁。早期诊断最为普遍：57.3%为I期，33.9%为II期，4.3%为III期或IV期。大多数患者（83.9%）接受手术治疗，仅9.5%接受单纯放疗。在接受手术治疗的8，405例患者中，68.6%接受了辅助治疗，包括化疗（20.9%），放疗（26.0%）和放化疗（21.9%）。在IA期患者中，16.0%接受了子宫体保留治疗。卵巢保留率为42.0%。结论.中华人民共和国的宫颈癌病例显示年轻患者和早期患者的患病率不断增加。在过去的10年中，手术已成为主要的治疗方法，并且越来越多地与I期和II期患者的辅助化疗相结合。保守手术方法是选择性患者生殖器官保留的合理选择。
Purpose. About one-third of the world's total annual new cervical cancer cases are found in the People's Republic of China. We investigate the prevalence and clinical characteristics of cervical cancer cases in the People's Republic of China over the past decade. Method. A total of 10,012 hospitalized patients with cervical cancer from regions nationwide were enrolled from 2000 to 2009. Demographic and clinical characteristics, therapeutic strategies, and outcomes were analyzed. Results. The mean age at diagnosis of all cervical cancer patients was 44.7 +/- 9.5 years, which is 5-10 years younger than mean ages reported before 2000 in the People's Republic of China. The age distribution showed 16.0% of patients were 45 years old. Early stage diagnoses were most prevalent: 57.3% were stage I, 33.9% were stage II, and 4.3% were stage III or IV. Most patients (83.9%) were treated with surgery, and only 9.5% had radiotherapy alone. Among 8,405 patients treated with surgery, 68.6% received adjuvant treatments, including chemotherapy (20.9%), radiotherapy (26.0%), and chemoradiotherapy (21.9%). Among stage IA patients, 16.0% were treated with corpus uteri preservation. The proportion of ovarian preservation was 42.0%. Conclusions. Cervical cancer cases in the People's Republic of China show increasing prevalence in young patients and at early stages. In the past 10 years, surgery has become the dominant treatment and is increasingly combined with adjuvant chemotherapy for patients with stages I and II. Conservative surgical approaches are reasonable options for genital organ preservation in selected patients.