H7N9 Influenza Viruses Are Transmissible in Ferrets by Respiratory Droplet
H7N9 Influenza Viruses Are Transmissible in Ferrets by Respiratory Droplet
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DOI：
10.1126/science.1240532
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发表时间：
2013-07-26
期刊：
影响因子：
56.9
通讯作者：
Chen, Hualan
中科院分区：
文献类型：
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作者：
Zhang, Qianyi;Shi, Jianzhong;Chen, Hualan
自2013年2月18日以来，新出现的H7N9病毒已在中国造成132人感染，其中37人死亡。在H7N9病毒阳性活禽市场采取的控制措施减少了感染人数；然而，该病毒的特性，包括其大流行的可能性，在很大程度上仍然未知。我们系统地分析了从禽类和人类分离的H7N9病毒。这些病毒在遗传上密切相关，并与人类气道受体结合；有些还保持了与鸟类气道受体结合的能力。从禽类中分离的病毒在鸡、鸭和小鼠中无致病性；然而，从人类身上分离出来的病毒使老鼠的体重减轻了30%。最重要的是，从人类分离的一种病毒通过呼吸道飞沫在雪貂中高度传播。我们的发现并不能减少人们对这些病毒可以在人与人之间传播的担忧。
A newly emerged H7N9 virus has caused 132 human infections with 37 deaths in China since 18 February 2013. Control measures in H7N9 virus-positive live poultry markets have reduced the number of infections; however, the character of the virus, including its pandemic potential, remains largely unknown. We systematically analyzed H7N9 viruses isolated from birds and humans. The viruses were genetically closely related and bound to human airway receptors; some also maintained the ability to bind to avian airway receptors. The viruses isolated from birds were nonpathogenic in chickens, ducks, and mice; however, the viruses isolated from humans caused up to 30% body weight loss in mice. Most importantly, one virus isolated from humans was highly transmissible in ferrets by respiratory droplet. Our findings indicate nothing to reduce the concern that these viruses can transmit between humans.