Either at left or right, both high and low frequency rTMS of dorsolateral prefrontal cortex decreases cue induced craving for methamphetamine
Either at left or right, both high and low frequency rTMS of dorsolateral prefrontal cortex decreases cue induced craving for methamphetamine
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无论在左侧还是右侧，背外侧前额叶皮层的高频和低频 rTMS 都会降低线索诱发的对甲基苯丙胺的渴望
DOI：
10.1111/ajad.12638
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发表时间：
2017-12-01
影响因子：
3.7
通讯作者：
Yuan, Ti-Fei
中科院分区：
文献类型：
--
作者：
Liu, Qingming;Shen, Ying;Yuan, Ti-Fei
背景与目的本研究旨在探讨左或右背外侧前额叶皮层在调节对毒品相关线索的渴求中是否起重要作用。方法在50名受试者中，采用左/右、高/低频率rTMS的不同组合，并在P3区进行主动假rTMS。结论双侧额叶对甲基苯丙胺的渴求具有明显的调节作用，但其机制不局限于单一脑区的增强或抑制，而是以前额皮质为靶点的经颅磁刺激对甲基苯丙胺的渴求具有明显的调节作用。(Am J Addict 2017;26：776-779）
Background and ObjectivesThe study is to investigate if left or right dorsolateral prefrontal cortex is important in modulating the craving to drug related cues.MethodsThe present investigation examined different combinations between left/right and high/low frequency rTMS on cue induced craving to methamphetamine, with active sham rTMS on P3 region on a total of 50 subjects.ResultsThe results showed that either at left or right side, both high and low frequency rTMS are effective in decreasing the cue induced craving to methamphetamine.Discussion and ConclusionsIn conclusion, bilateral frontal hemispheres are effective in modulating the cue induced craving to methamphetamine with rTMS.Scientific SignificanceTMS targeting prefrontal cortex is effective for craving modulation; however the mechanism is more than potentiation or depression of single brain region. (Am J Addict 2017;26:776-779)