Requirement for math5 in the development of retinal ganglion cells
Requirement for math5 in the development of retinal ganglion cells
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DOI：
10.1101/gad.855301
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发表时间：
2001-01-01
影响因子：
10.5
通讯作者：
Gan, L
中科院分区：
文献类型：
--
作者：
Wang, SW;Kim, BS;Gan, L
math 5是无调的小鼠直向同源物，无调是果蝇中光感受器和弦音器官形成所必需的bHLH前神经基因。math 5的表达与视网膜神经节细胞（RGC）分化的开始相一致。math 5的靶向缺失阻断了80%的RGCs的初始分化，并导致分化的无长突细胞增加。此外，math 5的缺乏消除了视网膜中brn-3b的表达，并消除了几乎所有表达brn-3b的RGCs的形成。这些结果表明，math 5是一个前神经基因RGC分化所必需的，math 5上游激活brn-3b依赖的分化过程中RGC。
math5 is a murine orthologue of atonal, a bHLH proneural gene essential for the formation of photoreceptors and chordotonal organs in Drosophila. The expression of math5 coincides with the onset of retinal ganglion cell (RGC) differentiation. Targeted deletion of math5 blocks the initial differentiation of 80% of RGCs and results in an increase in differentiated amacrine cells. Furthermore, the absence of math5 abolishes the retinal expression of brn-3b and the formation of virtually all brn-3b-expressing RGCs. These results imply that math5 is a proneural gene essential for RGC differentiation and that math5 acts upstream to activate brn-3b-dependent differentiation processes in RGCs.