Inhibitors of polyamine biosynthesis block human cytomegalovirus replication
Inhibitors of polyamine biosynthesis block human cytomegalovirus replication
复制标题
多胺生物合成抑制剂阻断人巨细胞病毒复制
DOI：
10.1038/297690a0
复制
发表时间：
1982
期刊：
影响因子：
64.8
通讯作者：
J. Williamson
中科院分区：
文献类型：
--
作者：
A. Tyms;J. Williamson
The antiviral activities of the few compounds available that are effective in the clinical treatment of virus infections are directed against nucleic acid synthesis1,2. Attention has been drawn recently to the need to develop new strategies, based on specific inhibitors of other biopolymers with essential functions in virus replication2. Polyamines may prove suitable targets, as these aliphatic bases are found in all animal cells, where they seem to have essential roles in the synthesis and stabilization of macromolecules3–5. Here we describe how human diploid fibroblasts (MRC5 cells) infected with human cytomegalovirus (CMV) have elevated levels of polyamines, and the polyamine antimetabolite methylglyoxal bis(guanylhydrazone) (MGB G) has potent antiviral activity. The growth of human CMV is also blocked by α-difluoromethylornithine (DFMO), a highly specific inhibitor of the initiation of polyamine biosynthesis. Cytochemical studies show this inhibitory effect is directed against early events in the virus replication cycle.
