How can mathematics help us explore vertebrate segmentation?
How can mathematics help us explore vertebrate segmentation?
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DOI：
10.2976/1.3072371
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发表时间：
2009-02-01
期刊：
影响因子：
--
通讯作者：
Schnell, Santiago
中科院分区：
文献类型：
--
作者：
Baker, Ruth E.;Schnell, Santiago
自从发现脊椎节段形成过程中基因产物的振荡，人们的注意力就集中在阐明所谓的节段钟的分子基础上。研究告诉我们，即使在最简单的脊椎动物中，非常复杂的基因网络也会在每个细胞中产生振荡，而细胞间的通讯会抑制相邻细胞之间的振荡。已经提出了许多理论来解释单个细胞中振荡的启动和维持以及细胞之间这种振荡的同步。我们在本评论中讨论这些理论。[DOI：10.2976/1.3072371]
Since the discovery of gene products oscillating during the formation of vertebral segments, much attention has been directed toward eluciating the molecular basis of the so-called segmentation clock. What research has told us is, that even in the most simple vertebrates, enormously complicated gene networks act in each cell to give rise to oscillations, and that cell-cell communication synchronizes these oscillations between neighboring cells. A number of theories have been proposed to explain both the initiation and maintenance of oscillations in a single cell and the synchronization of such oscillations between cells. We discuss these theories in this Commentary. [DOI: 10.2976/1.3072371]