Relationship of elevated 23Na magnetic resonance image intensity to infarct size after acute reperfused myocardial infarction
Relationship of elevated 23Na magnetic resonance image intensity to infarct size after acute reperfused myocardial infarction
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DOI：
10.1161/01.cir.100.2.185
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发表时间：
1999-07-13
期刊：
影响因子：
37.8
通讯作者：
Lima, JAC
中科院分区：
文献类型：
--
作者：
Kim, RJ;Judd, RM;Lima, JAC
背景：急性心肌梗死后Na-23 MR图像强度升高与高组织[Na+]和心肌活力丧失相对应。在这项研究中，我们探索了体内Na-23 MRI评估梗死面积的潜力，并研究了Na-23图像强度升高的可能机制。方法与结果：13只狗和8只家兔行冠状动脉原位闭塞再灌注，并行Na-23 MRI成像。对于解剖匹配的左心室短轴横切面（n=46），体内Na-23 MRI测量的梗死面积与三苯四唑氯染色具有良好的相关性(r=0.87, y=0.92x+3.37， P
Background-Elevated Na-23 MR image intensity after acute myocardial infarction has previously been shown to correspond to high tissue [Na+] and loss of myocardial viability. In this study, we explored the potential of in vivo Na-23 MRI to assess infarct size and investigated possible mechanisms for elevated Na-23 image intensity.Methods and Results-Thirteen dogs and 8 rabbits underwent in situ coronary artery occlusion and reperfusion and were imaged by Na-23 MRI. For anatomically matched left ventricular short-axis cross sections (n=46), infarct size measured by in vivo Na-23 MRI correlated well with triphenyltetrazolium chloride staining (r=0.87, y=0.92x+3.37, P