Rapid versus non-rapid cycling bipolar II depression: response to venlafaxine and lithium and hypomanic risk.
Rapid versus non-rapid cycling bipolar II depression: response to venlafaxine and lithium and hypomanic risk.
复制标题
快速与非快速循环双相 II 型抑郁症：对文拉法辛和锂的反应以及轻躁狂风险。
DOI：
10.1111/acps.12557
复制
发表时间：
2016
影响因子：
6.7
通讯作者：
DeRubeis,RJ
中科院分区：
文献类型：
--
作者：
Lorenzo-Luaces,L;Amsterdam,JD;Soeller,I;DeRubeis,RJ
目的探讨抗抑郁药与心境稳定剂单药治疗快速与非快速循环双相II型disorder.MethodSubjects ≥18岁的双相II型抑郁症（n= 129）的安全性和有效性随机双盲文拉法辛或碳酸锂单药治疗12周。应答者（n= 59）接受连续单药治疗6个月。ResultsRapid cycling并不影响响应频率或随时间变化的抑郁症状。快速循环状态不影响抑郁复发或持续治疗反应的频率。快速循环更有可能经历轻躁狂症状（P= 0.005）在连续单药治疗，然而，率相似，在文拉法辛（17.6%）和锂（42.9%）（P= 0.31）。结论快速循环状态可能不与风险增加减少反应或更大的抑郁复发，在文拉法辛，相对于锂单药治疗，双相II型受试者。需要更多的随机研究来证实这些发现。
ObjectiveTo examine the safety and effectiveness of antidepressant versus mood stabilizer monotherapy in rapid versus non‐rapid cycling bipolar II disorder.MethodSubjects ≥18 years old with bipolar II depression (n= 129) were randomized to double‐blind venlafaxine or lithium carbonate monotherapy for 12 weeks. Responders (n= 59) received continuation monotherapy for six additional months.ResultsRapid cycling did not affect frequency of response or change over time in depressive symptoms. Rapid cycling status did not affect frequency of depressive relapse or sustained treatment response. Rapid cyclers were more likely to experience hypomanic symptoms (P= 0.005) during continuation monotherapy; however, rates were similar in venlafaxine (17.6%) and lithium (42.9%) (P= 0.31).ConclusionRapid cycling status may not be associated with an increased risk of diminished response or greater depressive relapse during venlafaxine, relative to lithium monotherapy, in bipolar II subjects. Additional randomized studies are needed to confirm these findings.