Association between anticholinergic burden and dementia in UK Biobank.
Association between anticholinergic burden and dementia in UK Biobank.
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DOI：
10.1002/trc2.12290
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发表时间：
2022
影响因子：
4.8
通讯作者：
Muniz-Terrera, Graciela
中科院分区：
文献类型：
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作者：
Mur, Jure;Russ, Tom C;Cox, Simon R;Marioni, Riccardo E;Muniz-Terrera, Graciela
以往关于抗胆碱能药物与痴呆之间关系的研究报道了异质性结果。这种变异性可能是由于不同的抗胆碱能规模和不同类别的药物的差异性影响。使用考克斯比例风险模型，我们计算了2000年至2015年期间英国生物银行中年度抗胆碱能负担（AChB）与痴呆风险之间的关联，并与全科医生处方记录相关联（n = 171，775）。根据大多数抗胆碱能量表（标准化比值比范围：1.027-1.125）和AChB轨迹的斜率（风险比= 1.094; 95%置信区间：1.068-1.119）预测痴呆。然而，AChB和痴呆症之间的关联仅适用于某些类别的药物，特别是抗抑郁药，抗癫痫药和抗利尿药。以前研究结果的异质性可能部分是由于不同类别药物的不同作用。未来的研究应该建立更详细的差异，并进一步研究与痴呆症风险相关的AChB一般措施的实用性。
Previous studies on the relationship between anticholinergic drugs and dementia have reported heterogeneous results. This variability could be due to different anticholinergic scales and differential effects of distinct classes of drugs. Using Cox proportional hazards models, we computed the association between annual anticholinergic burden (AChB) and the risk of dementia in UK Biobank with linked general practitioner prescription records between the years 2000 and 2015 (n = 171,775). AChB according to most anticholinergic scales (standardized odds ratio range: 1.027–1.125) and the slope of the AChB trajectory (hazard ratio = 1.094; 95% confidence interval: 1.068–1.119) were predictive of dementia. However, the association between AChB and dementia held only for some classes of drugs, especially antidepressants, antiepileptics, and antidiuretics. The heterogeneity in previous findings may partially be due to different effects for different classes of drugs. Future studies should establish differences in more detail and further examine the practicality of a general measure of AChB relating to the risk of dementia.