Stable frequency of HIV-1 transmitted drug resistance in patients at the time of primary infection over 1996-2006 in France
Stable frequency of HIV-1 transmitted drug resistance in patients at the time of primary infection over 1996-2006 in France
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DOI：
10.1097/qad.0b013e328326ca77
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发表时间：
2009-03-27
期刊：
影响因子：
3.8
通讯作者：
Costagliola, Dominique
中科院分区：
文献类型：
--
作者：
Chaix, Marie-Laure;Descamps, Diane;Costagliola, Dominique
背景：耐药变异体的传播受多种因素的影响，包括HIV-1感染者体内HIV-1RNA水平。我们的研究描述了法国首次感染时确诊的1446名患者的传播耐药病毒情况，包括1996年至2006年，以及法国医院艾滋病毒数据库(FHDH)中慢性感染患者的比例。方法：在首次感染时进行基因耐药性测试。携带病毒的患者所占比例
Background: Transmission of drug-resistant variants is influenced by several factors, including the HIV-1 RNA levels in HIV-1-infected patients. Our study describes the transmitted drug-resistant virus among 1446 French patients diagnosed at the time of primary infection and included from 1996 to 2006 along with the proportion of chronically infected treated patients in the French Hospital Database on HIV (FHDH).Methods: Genotypic resistance tests were performed at the time of primary infection. The proportion of patients with viral load