Ultraviolet A in vitiligo
Ultraviolet A in vitiligo
复制标题
DOI：
10.1111/j.1600-0781.2006.00229.x
复制
发表时间：
2006-08-01
影响因子：
2.6
通讯作者：
Fawzy, Marwa
中科院分区：
文献类型：
--
作者：
El-Mofty, Medhat;Mostafa, Wedad;Fawzy, Marwa
两种类型的紫外线（UV）， UVB（290-320纳米）和UVA（320-400纳米），都会增加色素沉着或晒黑。然而，目前还没有单独评价UVA治疗白癜风的报道。因此，研究UVA（5和15 J/cm(2)）对白癜风的致色素作用是本研究的目的。本研究随机选取20例白癜风患者，患者体表面积超过30%，呈双侧/对称分布。他们被平均分为两组，每组10名患者。所有患者每周接受3次UVA治疗，第一组为15 J/cm(2)，第二组为5 J/cm(2)，共48次治疗，持续16周。在I组和II组中，分别有50%和10%的患者记录了60%及以上的总色素沉着。我们的结论是，单独使用宽带UVA，不使用补骨脂素，在适当的剂量下可能对白癜风有重要的治疗价值。
Both types of Ultraviolet (UV), UVB (290-320 nm) and UVA (320-400 nm), produce increased pigmentation or tanning. However, no evaluation of UVA alone in the treatment of vitiligo has been reported. Therefore, it was the purpose of this work to study the pigmentogenic effect of UVA (5 and 15 J/cm(2)) in vitiligo. The study included 20 randomly selected patients with vitiligo involving more than 30% of the body surface area with a bilateral/symmetrical distribution. They were equally divided into two groups each of 10 patients. All patients received three weekly sessions of UVA, 15 J/cm(2) in group I and 5 J/cm(2) in group II, a total of 48 sessions over 16 weeks. Overall pigmentation of 60% and above was recorded in 50% and 10% of patients in groups I and II, respectively. We conclude that broadband UVA alone, without psoralens, and in appropriate doses may be of important therapeutic value in vitiligo.