Oscillatory signaling and network responses during the development of Dictyostelium discoideum.
Oscillatory signaling and network responses during the development of Dictyostelium discoideum.
复制标题
盘基网柄菌发育过程中的振荡信号和网络反应。
DOI：
10.1016/j.arr.2008.04.003
复制
发表时间：
2008
影响因子：
13.1
通讯作者：
Kimmel,AlanR
中科院分区：
文献类型：
--
作者：
McMains,VanessaC;Liao,Xin-Hua;Kimmel,AlanR
Periodic biological variations reflect interactions among molecules and cells, or even organisms. The Dictyostelium cAMP oscillatory circuit is a highly robust example. cAMP oscillations in Dictyostelium arise intracellularly by a complex interplay of activating and inhibiting pathways, are transmitted extracellularly, and synchronize an entire local population. Once established, cAMP signal-relay persists stably for hours. On a two-dimensional surface, >100,000 cells may form a single coordinated territory. In suspension culture, >1010cells can oscillate in harmony. This review focuses on molecular mechanisms that cyclically activate and attenuate signal propagation and on chemotactic responses to oscillatory wave progression.
