Influence of castration on the electrical excitability and contraction properties of the rat levator ani muscle
Influence of castration on the electrical excitability and contraction properties of the rat levator ani muscle
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去势对大鼠提肛肌电兴奋性和收缩特性的影响
DOI：
10.1016/0014-4886(82)90026-7
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发表时间：
1982
影响因子：
5.3
通讯作者：
J. D. Valle
中科院分区：
文献类型：
--
作者：
C. Souccar;A. Lapa;J. D. Valle
2 （C2）、20 （C20）、75 （C75）日龄雄性大鼠阉割后，至105日龄时提肛肌（LA）明显萎缩。虽然单次抽搐时间延长，但c2和c20大鼠LA肌的抽搐张力和破伤风张力降低，而c75大鼠没有。去势后各组大鼠每克肌肉组织的最大收缩力均显著增加。在成年时阉割的大鼠（C75）给予睾酮可逆转阉割引起的变化。阉割对指长伸肌（EDL）特性的改变在数量上不如同一组的LA肌明显。然而，动物在阉割时越年轻，EDL的收缩特性受到的影响越大。去势对两种肌肉肌纤维的直接激发动作电位无显著影响。这些发现表明，去势对LA的影响以及对EDL的影响主要与睾酮对收缩系统发育和维持的营养影响有关。
Castration of male rats at 2 (C2), 20 (C20), or 75 (C75) days of age resulted in marked atrophy of the levator ani (LA) muscle by 105 days of age. Although the single twitch was prolonged, the twitch and tetanus tension were decreased in LA muscles from C2and C20rats but not from C75rats. However, the maximum force of contraction expressed per gram of muscle tissue was significantly increased after castration in all groups. Testosterone administration to rats castrated at adult age (C75) reversed the changes induced by castration. The alterations induced by castration on properties of the extensor digitorum longus (EDL) muscle were quantitatively less evident than those detected for the LA muscle in the same group. However, the younger the animal was at castration, the more affected were the contraction properties of the EDL. The directly elicited action potentials of the muscle fiber in both muscles were not significantly affected by castration. These findings suggest that the effect of castration on the LA and to a lesser extent on the EDL are primarily related to the trophic influence of testosterone on the development and maintenance of the contractile system.