Motor function in Parkinson's disease and supranuclear palsy: simultaneous factor analysis of a clinical scale in several populations.
Motor function in Parkinson's disease and supranuclear palsy: simultaneous factor analysis of a clinical scale in several populations.
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DOI：
10.1186/1471-2288-6-26
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发表时间：
2006-06-13
影响因子：
4
通讯作者：
Goetz, Christopher G
中科院分区：
文献类型：
--
作者：
Kroonenberg, Pieter M;Oort, Frans J;Goetz, Christopher G
背景技术背景：为了更好地了解不同患者组的运动行为的相似性和差异，同时分析了他们在统一帕金森病评定量表（UMRS）运动检查部分的得分。这三组分别由药物治疗的帕金森病（PD）患者、停用抗帕金森病药物至少12小时的帕金森病患者和诊断为特定帕金森综合征：进行性核上性麻痹（PSP）的患者组成。（294例PD接受药物治疗; 200例PD停止药物治疗：175例PSP）。由三个参与诊所的神经科医生执行了运动检查部分。记录每个项目的患者评分。为了评估这些样本中的CNORS组成部分之间的相似性和差异，我们对三组的协方差矩阵进行了同时或多组因素分析。此外，它被调查是否可以开发一个单一的模型的电机检查部分的EQUIPRS这将是有效的所有三个groups在同一时间。结果：一个单一的六维因子的解决方案被发现，适合所有组，虽然这是不直接的，由于震颤之间的差异，在休息变量。这些因素被确定为静止性震颤、姿势性震颤、轴功能障碍、僵硬、左侧运动迟缓和右侧运动迟缓。分析还指出PSP患者运动迟缓的偏侧化程度较低。各组运动障碍的强度不同，特别是在休息时震颤方面，但三组变量之间的总体关系是相同的。此外，除了从共同的因素结构的证据，在身体部位的具体和电机的具体方差的差异被发现。结论：从临床的角度来看，分析表明，使用电机检查部分的OHSAS也是合适的PSP患者，因为项目的相关结构是直接可比的帕金森氏症患者。从方法上讲，对所有群体的分析表明，可以非常详细地评估因素结构之间的相似性和差异。
BACKGROUND: In order to better understand the similarities and differences in the motor behaviour of different groups of patients, their scores on the Motor Examination section of the Unified Parkinson's Disease Rating Scale (UPDRS) were analysed simultaneously. The three groups consisted, respectively, of patients with Parkinson's disease (PD) on medication, patients with Parkinson's disease withdrawn from anti-parkinsonian medication for at least 12 hours, and patients diagnosed with a specific Parkinsonism syndrome: Progressive Supranuclear Palsy (PSP).METHODS: A total of 669 consecutively sampled patients from three separate hospital-based clinics participated (294 PD on medication; 200 PD off medication: 175 PSP). The Motor Examination section of the UPDRS was administered by neurologists at the three participating clinics. The patient scores on each item were recorded. To assess similarities and differences among the components of the UPDRS in these samples, we performed simultaneous or multigroup factor analysis on the covariance matrices of the three groups. In addition, it was investigated whether a single model for the Motor Examination section of the UPDRS could be developed which would be valid for all three groups at the same time.RESULTS: A single six-dimensional factor solution was found that fitted all groups, although this was not straightforward due to differences between the tremor-at-rest variables. The factors were identified as Tremor-at-rest, Postural Tremor, Axial Dysfunctioning, Rigidity, Left Bradykinesia and Right Bradykinesia. The analysis also pointed to a somewhat lower lateralization in bradykinesia for PSP patients. The groups differed in intensity of motor impairment, especially with respect to Tremor-at-Rest, but the overall relationships between the variables were shared by the three groups. In addition, apart from the common factor structure evidence of differences in body part-specific and motor-specific variances was found.CONCLUSION: From a clinical point of view, the analyses showed that using the Motor Examination section of the UPDRS is also appropriate for patients with PSP, because the correlational structure of the items is directly comparable to that of Parkinson's patients. Methodologically, the analysis of all groups together showed that it is possible to evaluate similarities and differences between factor structures in great detail.