Viscoelastic properties of human skin and processed dermis
Viscoelastic properties of human skin and processed dermis
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DOI：
10.1034/j.1600-0846.2001.007001018.x
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发表时间：
2001-02-01
影响因子：
2.2
通讯作者：
DeVore, D
中科院分区：
文献类型：
--
作者：
Silver, FH;Freeman, JW;DeVore, D
背景/目的：这项工作的目的是尝试确定皮肤中胶原蛋白和弹性纤维（弹性蛋白）的弹性弹簧常数，并确定这些弹性常数的值是否与其他组织报告的值相似。方法：我们通过测量增量应力应变行为来研究人体皮肤和真皮的粘弹性机械特性。使用弹性应力-应变曲线获得弹性蛋白和胶原蛋白的弹性弹簧常数，而胶原原纤维长度则从粘性应力-应变曲线的斜率获得。结果：我们的结果表明，弹性蛋白的弹性弹簧常数约为4.0 MPa，而胶原蛋白的弹性弹簧常数约为4.4 GPa。前一个值与项韧带的计算值相似，而后一个值约为肌腱和自组装 I 型胶原纤维的值的 70%。肌腱和皮肤中胶原蛋白分子的弹性常数之间的差异被推测反映了与肌腱相比，皮肤中发现的更高的分子倾斜角和更低的 D 周期以及更短的原纤维长度。结论：皮肤和肌腱中存在的胶原蛋白类型的差异可能会影响胶原蛋白的自组装和由此产生的粘弹性。
Background/aims: The purpose of this work is to attempt to determine the elastic spring constant for collagen and elastic fibers (elastin) in skin and to detemine if the values of these elastic constants are similar to those reported for other tissues.Methods: We studied the viscoelastic mechanical properties of human skin and dermis by measuring the incremental stress-strain behavior. Elastic stress-strain curves were used to obtain the elastic spring constant of elastin and collagen while the collagen fibril length was obtained from the slope of viscous stress-strain curves.Results: Our results suggest that the elastic spring constant for elastin is about 4.0 MPa while that for collagen is about 4.4 GPa. The former value is similar to that calculated for ligamentum nuchae while the latter value is about 70% of the value found for tendon and self-assembled type I collagen fibers. The differences between the elastic constants for collagen molecules in tendon and skin is hypothesized to reflect the higher molecular tilt angle and lower D period found in skin compared to tendon as well as a shorter fibril length.Conclusion: The differences in the collagen types present in skin and tendon may influence collagen self-assembly and the resulting viscoelastic properties.