Association of anergy with an immunosuppressive peptide fraction in the serum of patients with cancer.
Association of anergy with an immunosuppressive peptide fraction in the serum of patients with cancer.
复制标题
无反应性与癌症患者血清中免疫抑制肽成分的关联。
DOI：
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发表时间：
1974
影响因子：
158.5
通讯作者：
J. Mannick
中科院分区：
文献类型：
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作者：
A. Glasgow;R. Nimberg;J. Menzoian;I. Saporoschetz;S. Cooperband;K. Schmid;J. Mannick
为探讨肿瘤患者循环免疫抑制因子与无能的关系，我们对53例癌症患者进行了皮试抗原和2，4-二硝基氯苯过敏试验。在41例皮肤试验阴性的患者中，27例(66%)有免疫抑制血清(≥70%抑制植物血凝素的淋巴细胞刺激)。皮试阳性的12人中没有一人有免疫抑制血清。因此，无能和血清免疫抑制活性相关(p<；0.05)。经离子交换层析后，癌血清中的免疫抑制活性大部分在第一峰，组份I，而非癌症组分未检测到免疫抑制活性。癌血清的平均总免疫抑制活性为166.0±97.5S.D.单位，非癌血清为30.4±9.2单位(p<；0.05)。透析从癌症血清中分离的组份I产生了高度免疫抑制的组份(<；10,000道尔顿)。因此，安..。
Abstract To study the relation between circulating immunosuppressive factors and anergy in patients with cancer, we tested 53 patients with cancer for hypersensitivity to skin-test antigens and 2,4-dinitrochlorobenzene. Of 41 patients with negative skin tests, 27 (66 per cent) had immunosuppressive serum (≥70 per cent inhibition of lymphocyte stimulation by phytohemagglutinin). None of 12 with positive skin tests had immunosuppressive serum. Thus, anergy and serum immunosuppressive activity were correlated (p<0.05). After ion-exchange chromatography, most of the immunosuppressive activity in cancer serum was in the first peak, fraction I. The same fraction from subjects without cancer contained no detectable immunosuppressive activity. Mean total immunosuppressive activity of cancer serum was 166.0 ± 97.5 (S.D.) units, and that of non-cancer serum was 30.4 ± 9.2 units (p<0.05). Diafiltration of fraction I. from cancer serum yielded a fraction (< 10,000 daltons) that was highly immunosuppressive. Thus, ane...