Who put the "A" in Atg12: autophagy or apoptosis?

Who put the "A" in Atg12: autophagy or apoptosis?
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谁把Atg12中的“A”加进去了:自噬还是凋亡?

DOI:
10.1016/j.molcel.2011.12.007
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发表时间:
2011
期刊:
影响因子:
16
通讯作者:
Letai,Anthony
Letai,Anthony
中科院分区:
生物学1区
文献类型:
--
作者:
NiChonghaile,Triona;Letai,Anthony

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自噬和细胞凋亡这两种稳态途径是如何融合的,对此进行了大量的讨论。(2011)基于BH 3样结构域鉴定了自噬蛋白Atg 12的促凋亡作用,其能够结合和抑制抗凋亡Bcl-2家族蛋白。
Much deliberation surrounds how the two homeostatic pathways, autophagy and apoptosis, converge; in the December 9 issue ofMolecular Cell, Rubinstein et al. (2011) identify a proapoptotic role for the autophagic protein Atg12, based on a BH3-like domain, which enables binding and inhibition of antiapoptotic Bcl-2 family proteins.