Multiple pathways of cytochrome c release from mitochondria in apoptosis
Multiple pathways of cytochrome c release from mitochondria in apoptosis
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DOI：
10.1016/j.bbabio.2006.03.016
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发表时间：
2006-05-01
影响因子：
4.3
通讯作者：
Zhivotovsky, Boris
中科院分区：
文献类型：
--
作者：
Gogvadze, Vladimir;Orrenius, Sten;Zhivotovsky, Boris
尽管调节线粒体外膜透化和膜间空间蛋白释放的机制仍存在争议，但从线粒体释放细胞色素 c 是细胞凋亡过程中的关键主动步骤。在这里，我们讨论外膜透化的可能情况。膜间空间蛋白从线粒体释放的机制可能取决于细胞类型和细胞凋亡刺激的性质。导致外膜透化的多种机制可能解释了不同类型细胞中线粒体对多种凋亡刺激的反应的多样性。 (c) 2006 Elsevier B.V. 保留所有权利。
Release of cytochrome c from mitochondria is a key initiative step in the apoptotic process, although the mechanisms regulating permeabilization of the outer mitochondrial membrane and the release of intermembrane space proteins remain controversial. Here, we discuss possible scenarios of the outer membrane permeabilization. The mechanisms by which the intermembrane space proteins are released from mitochondria depend presumably on cell type and on the nature of the apoptotic stimulus. The variety of mechanisms that can lead to outer membrane permeabilization might explain diversities in the response of mitochondria to numerous apoptotic stimuli in different types of cells. (c) 2006 Elsevier B.V. All rights reserved.