Comparison of the native prothrombin antigen and the prothrombin time for monitoring oral anticoagulant therapy
Comparison of the native prothrombin antigen and the prothrombin time for monitoring oral anticoagulant therapy
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天然凝血酶原抗原和凝血酶原时间用于监测口服抗凝治疗的比较
DOI：
10.1182/blood.v64.2.445.445
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发表时间：
1984
期刊：
影响因子：
20.3
通讯作者：
S. Kruger
中科院分区：
文献类型：
--
作者：
B. Furie;H. Liebman;R. Blanchard;Coleman;S. Kruger
我们使用特异性免疫测定法测量了接受华法林钠治疗的患者的完全羧化（天然）凝血酶原抗原和羧化不足（异常）凝血酶原抗原，以评估监测口服抗凝治疗的新方法。测定血浆和血清样本（391）的凝血酶原时间、天然凝血酶原抗原和异常凝血酶原抗原。结果与放血时出血或血栓栓塞并发症的存在相关。 95% 的样本中天然凝血酶原抗原与并发症的发生相关。在来自出血并发症患者的 13 份样本中，13/13 (100%) 的天然凝血酶原为 12 微克/mL 或更低。在来自血栓栓塞并发症患者的 7 个样本中，6/7 (86%) 的天然凝血酶原为 24 微克/mL 或更高。相比之下，凝血酶原时间指数为 1.5 至 2.5、1.5 至 2.2、1.5 至 2.0 或 1.3 至 1.8 分别确定 6/20 (30%)、9/20 (45%)、11/20 (55%) 或 12/20 (60%) 的患者处于危险之中。尽管凝血酶原时间指数确实与出血并发症的存在相关，但天然凝血酶原抗原与出血和血栓栓塞并发症的存在密切相关。根据这些结果，通过定期调整华法林剂量将天然凝血酶原抗原维持在 12 至 24 微克/mL 范围内，可能与华法林治疗过量或不足引起的并发症风险降低有关。根据这些初步数据，我们建议考虑使用天然凝血酶原抗原来监测华法林治疗。
We have measured the fully carboxylated (native) prothrombin antigen and the undercarboxylated (abnormal) prothrombin antigen in patients treated with sodium warfarin using specific immunoassays to evaluate a new approach for monitoring oral anticoagulant therapy. Plasma and serum samples (391) were assayed for the prothrombin time, native prothrombin antigen, and abnormal prothrombin antigen. The results were correlated with the presence of bleeding or thromboembolic complications at the time of phlebotomy. The native prothrombin antigen correlated with the occurrence of complications in 95% of samples. Of 13 samples from patients with bleeding complications, 13/13 (100%) had a native prothrombin of 12 micrograms/mL or lower. Of seven samples from patients with thromboembolic complications, 6/7 (86%) had a native prothrombin of 24 micrograms/mL or greater. By comparison, a prothrombin time index of 1.5 to 2.5, 1.5 to 2.2, 1.5 to 2.0, or 1.3 to 1.8 identified 6/20 (30%), 9/20 (45%), 11/20 (55%), or 12/20 (60%) patients at risk, respectively. Although the prothrombin time index did correlate with the presence of bleeding complications, the native prothrombin antigen correlated closely with the presence of bleeding and thromboembolic complications. According to these results, the native prothrombin antigen, maintained in a range of 12 to 24 micrograms/mL by regular adjustment of the warfarin dosage, may be associated with a reduced risk of complications due to excessive or insufficient warfarin therapy. On the basis of these preliminary data, we recommend that the native prothrombin antigen be considered to monitor warfarin therapy.
DOI：
10.3109/10409238009105472
发表时间：
1980
期刊：
CRC critical reviews in biochemistry
影响因子：
--
作者：
Yale Nemerson;B. Furie
通讯作者：
Yale Nemerson;B. Furie
针对人凝血酶原的钙稳定结构的构象特异性单克隆抗体。
影响因子：
2.9
作者：
Lewis,RM;Furie,BC;Furie,B
通讯作者：
Furie,B
与功能性凝血活性相关的人类凝血酶原种类的免疫测定。
DOI：
--
发表时间：
1983
期刊：
The Journal of laboratory and clinical medicine
影响因子：
--
作者：
Blanchard,RA;Furie,BC;Kruger,SF;Waneck,G;Jorgensen,MJ;Furie,B
通讯作者：
Furie,B