Improvement of Platelet Respiration by Cell-Permeable Succinate in Diabetic Patients Treated with Statins.
Improvement of Platelet Respiration by Cell-Permeable Succinate in Diabetic Patients Treated with Statins.
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DOI：
10.3390/life11040288
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发表时间：
2021-03-28
期刊：
影响因子：
--
通讯作者：
Crețu OM
中科院分区：
文献类型：
--
作者：
Avram VF;Bîna AM;Sima A;Aburel OM;Sturza A;Burlacu O;Timar RZ;Muntean DM;Elmér E;Crețu OM
糖尿病(DM)是最严重的代谢性疾病，已达到全球大流行的水平，并与心血管疾病的高发病率有关。对于有或没有动脉粥样硬化病史的糖尿病患者，他汀类药物是一线降脂药物。虽然耐受性良好，但慢性治疗可能会导致副作用，导致治疗中断。线粒体功能障碍已成为糖尿病和他汀类药物引起的副作用的一种中枢病理机制。外周血小板线粒体呼吸的评估越来越多地被用作器官线粒体功能障碍的反映。本研究旨在评价他汀类药物对2型糖尿病患者线粒体呼吸的影响，以及(Ii)细胞通透性琥珀酸(NV118)对2型糖尿病患者血小板呼吸参数的影响。从接受阿托伐他汀或瑞舒伐他汀治疗的糖尿病患者分离的完整血小板的整体线粒体呼吸没有明显变化。同样，在接受阿托伐他汀治疗的糖尿病患者和健康对照组之间，没有发现通透性血小板线粒体呼吸的显著变化。急性体外注射NV118显著改善了分离的血小板的呼吸。这些结果促使进一步研究渗透性琥珀酸在代谢病理学中作为改善线粒体功能的治疗替代方案的作用，并指出外周血小板作为治疗反应的潜在生物标志物的作用。
Diabetes mellitus (DM) is the most severe metabolic disease that reached the level of a global pandemic and is associated with high cardiovascular morbidity. Statins are the first–line lipid–lowering therapy in diabetic patients with or without a history of atherosclerotic disease. Although well tolerated, chronic treatment may result in side effects that lead to treatment interruption. Mitochondrial dysfunction has emerged as a central pathomechanism in DM– and statin–induced side effects. Assessment of mitochondrial respiration in peripheral platelets has been increasingly used as a mirror of organ mitochondrial dysfunction. The present study aimed to assess the: (i) changes in mitochondrial respiration elicited by statins in patients with type 2 DM and (ii) the effects of cell–permeable succinate (NV118) on respiratory parameters in platelets harvested from these patients. No significant changes were found in global mitochondrial respiration of intact platelets isolated from diabetic patients treated with either atorvastatin or rosuvastatin. Similarly, no significant changes in mitochondrial respiration of permeabilized platelets were found between diabetic patients treated with atorvastatin and healthy controls. Acute ex vivo administration of NV118 significantly improved respiration in isolated platelets. These results prompt further research on the role of permeable succinate as a therapeutic alternative for improving mitochondrial function in metabolic pathologies and point to the role of peripheral platelets as a potential biomarker of treatment response.
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DOI：
10.1152/ajpendo.1998.275.2.e197
发表时间：
1998-08-01
影响因子：
5.1
作者：
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通讯作者：
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影响因子：
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影响因子：
3.2
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DOI：
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发表时间：
2016-06-01
期刊：
Archives of medical science : AMS
影响因子：
--
作者：
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影响因子：
8.2
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通讯作者：
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