Association of Early-life Exposure to Household Gas Appliances and Indoor Nitrogen Dioxide With Cognition and Attention Behavior in Preschoolers
Association of Early-life Exposure to Household Gas Appliances and Indoor Nitrogen Dioxide With Cognition and Attention Behavior in Preschoolers
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DOI：
10.1093/aje/kwp067
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发表时间：
2009-06-01
影响因子：
5
通讯作者：
Sunyer, Jordi
中科院分区：
文献类型：
--
作者：
Morales, Eva;Julvez, Jordi;Sunyer, Jordi
作者调查了学龄前儿童早期暴露于室内空气污染与神经心理发育的关系，并评估了这种关系是否因谷胱甘肽-S-转移酶基因（GSTP 1）多态性而不同。1997-1999年，在西班牙梅诺卡岛建立了一个前瞻性的、基于人口的出生队列（n = 482）。在4岁时对儿童的认知功能（麦卡锡儿童能力量表）和注意力多动行为（精神障碍诊断和统计手册，第4版）进行评估。在出生后的前3个月，在每个参与者的家中收集有关家中燃气器具和室内二氧化氮浓度的信息（n = 398，83%）。对GSTP 1编码变体Ile 105 Val进行基因分型。使用燃气器具与认知结果呈负相关（一般认知的β系数=-5.10，95%置信区间（CI）：-9.92，-0.28;注意力不集中症状的比值比= 3.59，95% CI：1.14，11.33），独立于社会阶层和其他混杂因素。二氧化氮浓度与认知功能（每1 ppb降低0.27分，95%CI：-0.48，-0.07）和注意力不集中症状（比值比= 1.06，95%CI：1.01，1.12）相关。在GSTP 1瓦尔-105等位基因的儿童中，来自燃气器具的室内污染对神经心理结果的有害影响更强。早期生活暴露于室内燃气器具的空气污染可能与生命最初4年的神经心理发育呈负相关，特别是在遗传易感儿童中。
The authors investigated the association of early-life exposure to indoor air pollution with neuropsychological development in preschoolers and assessed whether this association differs by glutathione-S-transferase gene (GSTP1) polymorphisms. A prospective, population-based birth cohort was set up in Menorca, Spain, in 1997-1999 (n = 482). Children were assessed for cognitive functioning (McCarthy Scales of Children's Abilities) and attention-hyperactivity behaviors (Diagnostic and Statistical Manual of Mental Disorders, 4th Edition) at age 4 years. During the first 3 months of life, information about gas appliances at home and indoor nitrogen dioxide concentration was collected at each participant's home (n = 398, 83%). Genotyping was conducted for the GSTP1 coding variant Ile105Val. Use of gas appliances was inversely associated with cognitive outcomes (beta coefficient for general cognition = -5.10, 95% confidence interval (CI): -9.92, -0.28; odds ratio for inattention symptoms = 3.59, 95% CI: 1.14, 11.33), independent of social class and other confounders. Nitrogen dioxide concentrations were associated with cognitive function (a decrease of 0.27 point per 1 ppb, 95% CI: -0.48, -0.07) and inattention symptoms (odds ratio = 1.06, 95% CI: 1.01, 1.12). The deleterious effect of indoor pollution from gas appliances on neuropsychological outcomes was stronger in children with the GSTP1 Val-105 allele. Early-life exposure to air pollution from indoor gas appliances may be negatively associated with neuropsychological development through the first 4 years of life, particularly among genetically susceptible children.