Inflammatory cytokines and mononuclear cells in sudden sensorineural hearing loss
Inflammatory cytokines and mononuclear cells in sudden sensorineural hearing loss
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DOI：
10.1017/s0022215119000100
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发表时间：
2019-02-01
影响因子：
1.7
通讯作者：
Jang, C. H.
中科院分区：
文献类型：
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作者：
Yoon, S. H.;Kim, M. E.;Jang, C. H.
目的探讨单侧突聋患者外周血单个核细胞、肿瘤坏死因子α（TNF-α）、白细胞介素10（IL-10）、白细胞介素12（IL-12）、干扰素γ（IFN-γ）水平及分化抗原17 c、86表达的变化。方法选择24例单侧突发性耳聋患者和24例听力正常、无突发性耳聋病史（因其他原因就诊）的患者。分离并分析外周血单核细胞和分化簇11 c和86。测量了肿瘤坏死因子-α、干扰素-γ和白细胞介素10和12的血浆和上清液水平。结果不同年龄、性别间无显著性差异。与对照组相比，研究组的单核细胞数量、平均肿瘤坏死因子-α水平和分化簇86表达显著增加。然而，干扰素-γ和白细胞介素12水平显着下降。平均白细胞介素10水平差异不显著。结论肿瘤坏死因子-α和单核细胞数量的增加可能在突发性耳聋的发病中起重要作用。这就需要对树突状细胞在突发性耳聋中的作用进行深入的研究。
Objective This study evaluated tumour necrosis factor-alpha, interleukins 10 and 12, and interferon-gamma levels, peripheral blood mononuclear cells, and clusters of differentiation 17c and 86 expression in unilateral sudden sensorineural hearing loss. Methods Twenty-four patients with unilateral sudden sensorineural hearing loss, and 24 individuals with normal hearing and no history of sudden sensorineural hearing loss (who were attending the clinic for other problems), were enrolled. Peripheral blood mononuclear cells, and clusters of differentiation 11c and 86 were isolated and analysed. Plasma and supernatant levels of tumour necrosis factor-alpha, interferon-gamma, and interleukins 10 and 12 were measured. Results There were no significant differences with respect to age and gender. Monocyte population, mean tumour necrosis factor-alpha level and cluster of differentiation 86 expression were significantly increased in the study group compared to the control group. However, interferon-gamma and interleukin 12 levels were significantly decreased. The difference in mean interleukin 10 level was not significant. Conclusion Increases in tumour necrosis factor-alpha level and monocyte population might play critical roles in sudden sensorineural hearing loss. This warrants detailed investigation and further studies on the role of dendritic cells in sudden sensorineural hearing loss.