Prostate cancer characteristics in the World Trade Center cohort, 2002-2013.
Prostate cancer characteristics in the World Trade Center cohort, 2002-2013.
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DOI：
10.1097/cej.0000000000000315
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发表时间：
2018-07
期刊：
影响因子：
--
通讯作者：
Taioli E
中科院分区：
文献类型：
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作者：
Hashim D;Boffetta P;Galsky M;Oh W;Lucchini R;Crane M;Luft B;Moline J;Udasin I;Harrison D;Taioli E
据报道，在世界贸易中心（WTC）的三个队列中，前列腺癌的发病率有所增加。目前尚不清楚这一增长是由于与WTC有关的暴露还是由于加强了监督。前列腺癌病例（2002-2013年）来自WTC健康计划。将年龄、种族和Gleason评分分布与同一时期的纽约州癌症登记处（NYSCR）病例进行比较。多变量模型根据年龄和种族进行调整。还对队列中前列腺癌病例的临床特征进行了分析，调整了年龄、种族和WTC暴露类别。WTC受访者的前列腺癌年龄标准化比率为1.65（95% CI：1.37，1.93）与纽约州相比; 30-49岁的年龄特异性比率最高（2.28; 95% CI：1.51-3.43）、70-74（2.05; 95% CI：1.03-4.10）和80-84岁（5.65; 95% CI：1.41-22.58）。高WTC暴露与晚期临床分期相关（5.58; 95% CI：1.05-29.76; p趋势=0.03）。与纽约州整体相比，世贸中心受访者的前列腺癌发病率仍然较高。WTC暴露水平较高的受访者可能患有更晚期的前列腺癌。
An increased incidence of prostate cancer was reported in three cohorts of World Trade Center (WTC) respondents. It is uncertain whether this increase is due to WTC-related exposures or enhanced surveillance. Prostate cancer cases (2002-2013) were obtained from the WTC Health Program. Age, race and Gleason score distribution were compared to New York State Cancer Registry (NYSCR) cases from the same time period. Multivariate models were adjusted for age and race. Analyses of clinical characteristics of prostate cancer cases within the cohort were also performed, adjusting for age, race, and WTC exposure categories. WTC respondents had a prostate cancer age-standardized rate ratio of 1.65 (95% CI: 1.37, 1.93) compared to New York state; age-specific ratios were highest for ages 30-49 (2.28; 95% CI: 1.51-3.43), 70-74 (2.05; 95% CI: 1.03-4.10), and 80-84 years (5.65; 95% CI: 1.41-22.58). High WTC exposure was associated with advanced clinical stage (5.58; 95% CI: 1.05-29.76; p-trend=0.03). WTC respondents continue to have higher prostate cancer rate compared to NYS as a whole. Respondents with a higher WTC exposure level may have had more advanced clinical stage of prostate cancer.