Post-myocardial infarction left ventricular myocyte remodeling: are there gender differences in rats?
Post-myocardial infarction left ventricular myocyte remodeling: are there gender differences in rats?
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DOI：
10.1016/j.carpath.2010.09.007
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发表时间：
2011-09-01
期刊：
影响因子：
--
通讯作者：
Gerdes, Anthony Martin
中科院分区：
文献类型：
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作者：
Chen, Yue-Feng;Redetzke, Rebecca A;Gerdes, Anthony Martin
背景：先前的研究已经显示了心肌梗死后左心室重构的性别差异。然而，结果是多种多样的，并且没有可靠的、全面的心肌细胞形状变化的数据。方法：选取年轻成年雌性和雄性Sprague-Dawley大鼠，随机分为心肌梗死组和假性心肌梗死组。结扎左冠状降支引起心肌梗死。术后4周进行左心室超声心动图和血流动力学检查，然后分离心肌细胞进行大小测定。结果：一般情况下，心肌梗死后左心室功能变化具有可比性。女性的左心室肥厚比男性轻微但明显，这反映在左心室肌细胞体积的相对增加上。然而，在男性和女性中，肌细胞肥大完全是由于肌细胞的延长而没有改变肌细胞的横截面积。结论：本研究表明，年轻成年雄性和雌性大鼠心肌梗死后左室功能和心肌细胞重塑的变化非常相似。
BACKGROUND: Previous studies have shown gender differences in left ventricular remodeling after myocardial infarction. Results are varied, however, and reliable, comprehensive data for changes in cardiac myocyte shape are not available.METHODS: Young adult female and male Sprague-Dawley rats were used in this study and randomly assigned to the myocardial infarction and sham myocardial infarction groups. Myocardial infarction was produced by ligation of the left descending coronary artery. Four weeks after surgery, left ventricular echocardiography and hemodynamics were performed before isolating myocytes for size determination.RESULTS: In general, left ventricular functional changes after myocardial infarction were comparable. Females developed slightly, but significantly, more left ventricular hypertrophy than males, and this was reflected by the relative increases in left ventricular myocyte volume. In both males and females, however, myocyte hypertrophy was due exclusively to lengthening of myocytes with no change in myocyte cross-sectional area.CONCLUSIONS: This study demonstrates that post-myocardial infarction changes in LV function and myocyte remodeling are remarkably similar in young adult male and female rats.