Evaluation of spin in the abstracts of systematic reviews and meta-analyses focused on the treatment of obesity
Evaluation of spin in the abstracts of systematic reviews and meta-analyses focused on the treatment of obesity
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DOI：
10.1002/oby.23192
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发表时间：
2021-08-01
期刊：
影响因子：
6.9
通讯作者：
Vassar, Matt
中科院分区：
文献类型：
--
作者：
Faulkner, Jantzen J.;Polson, Connor;Vassar, Matt
客观自旋，即，对研究结果的歪曲，有可能影响病人的护理。有证据表明，旋转在肥胖随机对照试验中很普遍。因此，本研究的主要目的是评价涉及肥胖治疗的系统性综述摘要中的自旋。方法计算机检索MEDLINE和Embase中有关肥胖症治疗的系统评价。对每份系统性综述摘要进行了9种最严重的旋转类型的检查，即，通过夸大或遗漏对研究结果的歪曲，无论其意图如何。筛选和数据提取以设盲、一式三份的方式进行。方法学质量的确定使用测量工具评估系统评价（AMSTAR-2）。结果在20篇（共200篇，10%）摘要中发现了自旋，其中自旋类型5（声称有效，尽管主要研究中存在高偏倚风险）最常见（11/200，5.5%）。未发现与不支持的疗效声明相关的旋转类型2和7。未发现旋转与提取的研究特征之间的关联。样本的方法学质量评级如下：极低（23.0%）、低（13.5%）、中等（60.5%）和高（3%）。结论：虽然这些研究结果表明，在肥胖治疗的系统评价摘要中，自旋的比例很低，但增加预防措施可能会进一步减少其存在。
Objective Spin, i.e., the misrepresentation of research findings, has the potential to affect patient care. Evidence suggests that spin is prevalent in obesity randomized controlled trials. Therefore, the primary objective of this study was to evaluate spin in abstracts of systematic reviews covering obesity treatments. Methods MEDLINE and Embase were searched to retrieve systematic reviews on obesity treatments. Each systematic review abstract was inspected for the nine most severe types of spin, i.e., the misrepresentation of study findings by exaggeration or omission, regardless of intentionality. Screening and data extraction occurred in a masked, triplicate fashion. Methodological quality was determined using A MeaSurement Tool to Assess systematic Reviews (AMSTAR-2). Results Spin was identified in 20 (out of 200, 10%) abstracts, with spin type 5 (claiming efficacy despite high risk of bias among primary studies) being most common (11/200, 5.5%). Spin types 2 and 7, both related to unsupported efficacy claims, were not found. No associations were found between spin and extracted study characteristics. The methodological quality of the sample was rated as follows: critically low (23.0%), low (13.5%), moderate (60.5%), and high (3%). Conclusions Although these findings demonstrate a low proportion of spin in the abstracts of systematic reviews for obesity treatment; increased preventive measures may further reduce its presence.