Circadian regulation dominates homeostatic control of sleep length and prior wake length in humans.
Circadian regulation dominates homeostatic control of sleep length and prior wake length in humans.
复制标题
昼夜节律调节主导着人类睡眠长度和前觉醒时间长度的稳态控制。
作者：
S. Strogatz;R. Kronauer;C. Czeisler
在洞穴或没有窗户的房间里长时间的时间隔离期间，人类受试者通常会发展出复杂的睡眠-觉醒模式。为了在这些模式中寻找合法的结构，我们重新分析了15名内部去睡眠化的人类受试者记录的359个睡眠-觉醒周期的自发时间。观察到的睡眠-觉醒模式遵循一个简单的规则：就寝时的昼夜温度节律的相位决定了先前觉醒（alpha）和随后睡眠（rho）的长度。从这个规则中，我们得到一个平均α：ρ关系，取决于昼夜节律的阶段。该关系调和了在同步受试者中观察到的负α：ρ相关性与在去同步受试者中发现的正α：ρ相关性。我们最令人惊讶的结果是关于α和ρ与其昼夜节律相位调整平均值的残余偏差。我们报告说，有没有显着的正相关性之间的残差α和ρ，相反的预测恢复模型的睡眠时间。我们的发现阐明了睡眠调节的机制，并提供了急需的睡眠-觉醒周期数学模型的测试。
During prolonged temporal isolation in caves or windowless rooms, human subjects often develop complicated sleep-wake patterns. Seeking lawful structure in these patterns, we have reanalyzed the spontaneous timing of 359 sleep-wake cycles recorded from 15 internally desynchronized human subjects. The observed sleep-wake patterns obey a simple rule: The phase of the circadian temperature rhythm at bedtime determines the lengths of both prior wake (alpha) and subsequent sleep (rho). From this rule we derive an average alpha:rho relationship that depends on circadian phase. The relationship reconciles the established negative alpha:rho correlation observed in synchronized subjects with the positive alpha:rho correlation found in desynchronized subjects. Our most surprising result concerns the residual deviations of alpha and rho from their circadian phase-adjusted mean values. We report that there is no significant positive correlation between the residuals of alpha and rho, contrary to the prediction of restorative models of sleep duration. Our findings illuminate the mechanisms underlying sleep regulation and provide much-needed tests of mathematical models of the sleep-wake cycle.
影响因子：
56.9
作者：
CZEISLER, CA;WEITZMAN, ED;KNAUER, RS
通讯作者：
KNAUER, RS