Auditory training during development mitigates a hearing loss-induced perceptual deficit.
Auditory training during development mitigates a hearing loss-induced perceptual deficit.
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DOI：
10.3389/fnsys.2014.00049
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发表时间：
2014
影响因子：
3
通讯作者：
Sanes DH
中科院分区：
文献类型：
--
作者：
Kang R;Sarro EC;Sanes DH
在早期发展过程中的感觉经验可以塑造中枢神经系统，这被认为会影响成年人的感知技能。在听觉系统中，传导性听力损失（CHL）的早期诱导导致成年动物中枢听觉编码特性的缺陷，并且这伴随着感知阈值的降低。相比之下，在发育过程中进行简短的听觉训练可以增强动物在成年后进行测试时的感知技能。在这里，我们问是否在发展过程中的短期培训可以弥补与CHL饲养的成年动物所表现出的知觉缺陷。青少年沙鼠与CHL，年龄匹配的控制，训练调频（FM）检测任务4或10天。随后在成年期评估每组的表现，并与听力正常（NH）的成年人或未接受青少年训练的CHL成年人进行比较。我们发现，作为青少年，CHL和NH动物显示出类似的FM检测阈值，不会立即受到知觉训练的影响。然而，成年后，这些动物的检测阈值和心理功能斜率显着改善。重要的是，青少年训练的CHL成人显示接近NH成人的阈值。此外，我们发现，训练10天的听力受损动物显示出的成年阈值比训练4天的成年阈值更接近未经训练的成年阈值。因此，一个相对较短的时间段的听觉训练可以补偿听觉剥夺对训练任务的听觉感知的有害影响。
Sensory experience during early development can shape the central nervous system and this is thought to influence adult perceptual skills. In the auditory system, early induction of conductive hearing loss (CHL) leads to deficits in central auditory coding properties in adult animals, and this is accompanied by diminished perceptual thresholds. In contrast, a brief regimen of auditory training during development can enhance the perceptual skills of animals when tested in adulthood. Here, we asked whether a brief period of training during development could compensate for the perceptual deficits displayed by adult animals reared with CHL. Juvenile gerbils with CHL, and age-matched controls, were trained on a frequency modulation (FM) detection task for 4 or 10 days. The performance of each group was subsequently assessed in adulthood, and compared to adults with normal hearing (NH) or adults raised with CHL that did not receive juvenile training. We show that as juveniles, both CHL and NH animals display similar FM detection thresholds that are not immediately impacted by the perceptual training. However, as adults, detection thresholds and psychometric function slopes of these animals were significantly improved. Importantly, CHL adults with juvenile training displayed thresholds that approached NH adults. Additionally, we found that hearing impaired animals trained for 10 days displayed adult thresholds closer to untrained adults than those trained for 4 days. Thus, a relatively brief period of auditory training may compensate for the deleterious impact of hearing deprivation on auditory perception on the trained task.