Hypothalamic-pituitary-adrenal axis reactivity to psychological stress and memory in middle-aged women: high responders exhibit enhanced declarative memory performance
Hypothalamic-pituitary-adrenal axis reactivity to psychological stress and memory in middle-aged women: high responders exhibit enhanced declarative memory performance
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DOI：
10.1016/s0306-4530(01)00085-3
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发表时间：
2002-10-01
影响因子：
3.7
通讯作者：
Hautzinger, M
中科院分区：
文献类型：
--
作者：
Domes, G;Heinrichs, A;Hautzinger, M
根据最近的研究，皮质醇水平升高与陈述性记忆表现受损有关。皮质醇的这种特殊作用已经在几项使用药理学剂量的皮质醇的研究中得到证实。本研究旨在确定内源性刺激皮质醇分泌对健康中年女性记忆表现的影响。对于心理压力挑战，我们采用了特里尔社会压力测试（TSST）。受试者被分配到TSST或非压力控制条件。陈述性记忆和非陈述性记忆的表现是由一个组合的无启动回忆任务。没有显着的组间差异被发现的记忆性能。事后方差分析表明，无论实验条件下的显着高皮质醇增加的实验程序（高反应者）的受试者表现出增加的记忆表现在陈述性任务相比，低皮质醇反应（低反应者）。结果表明，应激诱导的皮质醇未能损害记忆表现。结果进行了讨论与性别特异性的影响和交感神经系统和心理变量的调节作用。(C)2002爱思唯尔科技有限公司版权所有。
According to recent studies, elevated cortisol levels are associated with impaired declarative memory performance. This specific effect of cortisol has been shown in several studies using pharmacological doses of cortisol. The present study was designed to determine the effects of endogenously stimulated cortisol secretion on memory performance in healthy middle-aged women. For psychological stress challenging, we employed the Trier Social Stress Test (TSST). Subjects were assigned to either the TSST or a non-stressful control condition. Declarative and non-declarative memory performance was measured by a combined priming-free-recall-task. No significant group differences were found for memory performance. Post hoc analyses of variance indicated that regardless of experimental condition the subjects with remarkably high cortisol increase in response to the experimental procedure (high responders) showed increased memory performance in the declarative task compared to subjects with low cortisol response (low responders). The results suggest that stress-induced cortisol failed to impair memory performance. The results are discussed with respect to gender-specific effects and modulatory effects of the sympathetic nervous system and psychological variables. (C) 2002 Elsevier Science Ltd. All rights reserved.