Decreased Maternal Plasma Apelin Concentrations in Preeclampsia
Decreased Maternal Plasma Apelin Concentrations in Preeclampsia
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DOI：
10.3109/10641955.2012.690054
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发表时间：
2012-01-01
影响因子：
1.5
通讯作者：
Maitra, Rangan
中科院分区：
文献类型：
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作者：
Bortoff, Katherine D.;Qiu, Chunfang;Maitra, Rangan
背景先兆子痫是一种高血压疾病，使3-7%的妊娠并发症。先兆子痫的发展尚未完全阐明，目前的治疗方法并不广泛有效。apelinergic系统似乎参与高血压疾病，实验研究表明该系统在先兆子痫中的作用。因此，在孕妇的病例对照研究中进行血浆中爱帕琳蛋白浓度的流行病学评价。方法.数据和母体血浆样品收集自患有确诊的先兆子痫的孕妇（n = 76）或血压正常的对照（n = 79）。使用酶联免疫吸附测定法盲测爱帕琳肽的浓度。对数据进行统计分析。结果在分娩时测量的血浆爱帕琳素浓度在先兆子痫病例中低于对照组（平均值+/-标准差：0.66 +/- 0.29 vs. 0.78 +/- 0.31 ng/mL，p = 0.02）。在控制了母亲年龄、吸烟状况和孕前体重指数的混杂因素后，血浆apelin水平高的妇女与血浆apelin水平低的妇女相比，先兆子痫的几率低48%（>= 0.73 vs.
Background. Preeclampsia is a hypertensive disorder that complicates 3-7% of pregnancies. The development of preeclampsia has not been completely elucidated and current therapies are not broadly efficacious. The apelinergic system appears to be involved in hypertensive disorders and experimental studies indicate a role of this system in preeclampsia. Thus, an epidemiological evaluation of apelin protein concentration in plasma was conducted in case-control study of pregnant women. Methods. Data and maternal plasma samples were collected from pregnant women with confirmed preeclampsia (n = 76) or normotensive controls (n = 79). Concentrations of apelin peptides were blindly measured using enzyme-linked immunosorbent assay. Data were subjected to statistical analyses. Results. Plasma apelin concentrations, measured at delivery, were lower in preeclampsia cases compared with controls (mean +/- standard deviation: 0.66 +/- 0.29 vs. 0.78 +/- 0.31 ng/mL, p = 0.02). After controlling for confounding by maternal age, smoking status, and pre-pregnancy body mass index, odds of preeclampsia were 48% lower for women with high versus low plasma apelin (>= 0.73 vs.