Hydroaminomethylation with novel rhodium-carbene complexes: An efficient catalytic approach to pharmaceuticals
Hydroaminomethylation with novel rhodium-carbene complexes: An efficient catalytic approach to pharmaceuticals
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DOI：
10.1002/chem.200601155
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发表时间：
2007-01-01
影响因子：
4.3
通讯作者：
Beller, Matthias
中科院分区：
文献类型：
--
作者：
Ahmed, Moballigh;Buch, Cathleen;Beller, Matthias
以[（Rh（cod）Cl）21和1，3-二均三甲苯基咪唑-2-亚基为原料，合成了新型[RhCl（cod）（卡宾）]配合物1-5，并对其进行了表征和芳香烯烃氢氨甲基化反应的研究。以1，1-二苯基乙烯和哌啶为模型体系，详细考察了不同配体和反应参数对催化活性的影响。新型催化剂的范围和局限性显示在16个生物活性的1-氨基-3，3-二芳基丙烯的制备中。在一般情况下，高的化学和区域选择性以及良好的产率所需的产品实现。
Starting from [jRh(cod)Cl)21 and 1,3-dimesitylimidazole-2-ylidenes the novel [RhCl(cod)(carbene)] complexes 1-5 have been synthesized, characterized, and tested in the hydroaminomethylation of aromatic olefins. The influence of different ligands and reaction parameters on the catalytic activitywas investigated in detail applying 1,1diphenylethylene and piperidine as a model system. The scope and limitations of the novel catalysts is shown in the preparation of 16 biologically active 1-amino-3,3-diarylpropenes. In general, high chemo- and regioselectivity as well as good yields of the desired products were achieved.