Analysis of opioid receptor subtype antagonist effects upon mu opioid agonist-induced feeding elicited from the ventral tegmental area of rats
Analysis of opioid receptor subtype antagonist effects upon mu opioid agonist-induced feeding elicited from the ventral tegmental area of rats
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DOI：
10.1016/s0006-8993(01)03382-0
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发表时间：
2002-03-01
期刊：
影响因子：
2.9
通讯作者：
Bodnar, RJ
中科院分区：
文献类型：
--
作者：
Lamonte, N;Echo, JA;Bodnar, RJ
本研究采用一般或选择性阿片受体拮抗剂预处理，检查了腹侧被盖区μ阿片受体激动剂引起的阿片受体介导的摄食。纳洛酮以及等摩尔剂量的选择性mu和kappa，但不是δ阿片类拮抗剂在腹侧被盖区显着减少mu激动剂诱导的进食，表明这些受体亚型在充分表达这种反应的关键作用。(C)2002 Elsevier Science B.V.保留所有权利。
The present study examined opioid receptor(s) mediation of feeding elicited by mu opioid agonists in the ventral tegmental area using general or selective opioid antagonist pretreatment. Naltrexone as well as equimolar doses of selective mu and kappa, but not delta opioid antagonists in the ventral tegmental area significantly reduced mu agonist-induced feeding, indicating a pivotal role for these receptor subtypes in the full expression of this response. (C) 2002 Elsevier Science B.V. All rights reserved.