Odor memory and odor learning in rats with lesions of the lateral olfactory tract and mediodorsal thalamic nucleus
Odor memory and odor learning in rats with lesions of the lateral olfactory tract and mediodorsal thalamic nucleus
复制标题
外侧嗅束和丘脑内侧核损伤大鼠的气味记忆和气味学习
DOI：
10.1016/0006-8993(90)90807-n
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发表时间：
1990
期刊：
影响因子：
2.9
通讯作者：
Judith M. Risser
中科院分区：
文献类型：
--
作者：
B. Slotnick;Judith M. Risser
大鼠后横断外侧嗅束（LOT），病变的丘脑背内侧核（MD），或与这些结构的组合病变进行了测试，保留术前学习的多种气味的歧视任务，收购3个简单的2-气味的歧视问题，和逆转的最后一个问题的系列。与对照组相比，LOT横断大鼠在任何任务中均无缺陷。MD损伤者在记忆力方面没有缺陷，但在新气味辨别能力的获得方面有中度缺陷，在逆转学习方面有严重缺陷。合并LOT和MD病变的大鼠没有保留术前学习的任务，但他们对剩余问题的表现与仅MD病变的大鼠相似。这些结果表明，无论是嗅觉丘脑皮质的预测，也不杏仁核或内嗅皮质的存储和/或回忆的嗅觉程序记忆任务是必不可少的。结果表明，在嗅觉辨别学习中，丘脑皮质的嗅觉投射起重要作用，而边缘系统的嗅觉投射则不起重要作用。
Rats with posterior transection of the lateral olfactory tract (LOT), lesions of the mediodorsal thalamic nucleus (MD), or with combined lesions of these structures were tested for retention of a preoperatively learned multiple odor discrimination task, acquisition of 3 simple 2-odor discrimination problems, and reversal of the last problem of the series. Compared to controls, rats with transection of the LOT had no deficits in any task. Those with MD lesions had no deficits in retention but moderate deficits in acquisistion of novel odor discriminations and a severe deficit in reversal learning. Rats with combined LOT and MD lesions had no retention of the preoperatively learned task but their performance on the remaining problems was similar to that of rats with only MD lesions. These results suggest that neither the olfactory thalamocortical projections nor those to the periamygdaloid or entorhinal cortex are essential for storage and/or recall of an olfactory procedural memory task. Performance on the postoperative acquisition tests indicate that the thalamocortical but not the limbic olfactory projections play an important role in olfactory discrimination learning.