Neuronal targets of serum and cerebrospinal fluid autoantibodies in amyotrophic lateral sclerosis
Neuronal targets of serum and cerebrospinal fluid autoantibodies in amyotrophic lateral sclerosis
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肌萎缩侧索硬化症血清和脑脊液自身抗体的神经元靶标
DOI：
10.1007/s004010050393
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发表时间：
1995
影响因子：
12.7
通讯作者：
A. Marx
中科院分区：
文献类型：
--
作者：
A. Greiner;B. Schmausser;Klaus Petzold;H. Krüger;A. Marx
应用免疫荧光法对25例肌萎缩侧索硬化（ALS）患者的血清和脑脊液（CSF）中的自身抗体进行了检测。将结果与正常献血者（n = 45）和其他神经系统疾病（OND）患者（n = 11）的对照血清进行比较。三种不同类型的组织反应性（神经胶质，轴突，和小血管）被发现。抗体结合到神经胶质和轴突结构中发现ALS患者的32%，相比之下，12%的正常和27%的OND控制。与此相反，染色的内皮细胞被发现与24%的ALS血清和CSF，但不与正常和OND对照血清，并证明只有胎儿和青少年的神经组织和腓肠神经活检的两个5 ALS患者。然而，正常或发炎的成人CNS/PNS组织不被这些血清染色。我们的结论是，ALS是最有可能是一个异质性组的疾病，只有一个亚组的ALS可能有自身免疫性发病机制。因此，这些发现可能对ALS的任何免疫抑制治疗的评价具有影响。
Abstract Sera and cerebrospinal fluid (CSF) from 25 patients with amyotrophic lateral sclerosis (ALS) were tested by immunofluorescence on fetal, juvenile and adult central and peripheral neuronal (CNS/PNS) tissues and on nerve biopsy material from affected patients for the presence of autoantibodies. Results were compared with control sera from normal blood donors (n = 45) and patients with other neurological diseases (OND) (n = 11). Three different types of tissue reactivity (glial, axonal, and small blood vessels) were found. Antibodies binding to glial and axonal structures were found in 32% of ALS patients as compared to 12% in normal and 27% in OND controls. In contrast, staining of endothelial cells was found with 24% of ALS sera and CSF but not with normal and OND control sera and was demonstrated only with fetal and juvenile nervous tissue and with suralis nerve biopsies of two of five ALS patients. However, normal or inflamed adult CNS/PNS tissue was not stained with these sera. We conclude that ALS is most likely a heterogeneous group of diseases and only a subgroup of ALS may have an autoimmune pathogenesis. These findings may, therefore, have implications for the evaluation of any immunosuppressive treatment in ALS.
DOI：
--
发表时间：
1992-03
期刊：
The American journal of pathology
影响因子：
--
作者：
T. Kawamata;H. Akiyama;T. Yamada;P. Mcgeer
通讯作者：
T. Kawamata;H. Akiyama;T. Yamada;P. Mcgeer
影响因子：
158.5
作者：
ROTHSTEIN, JD;MARTIN, LJ;KUNCL, RW
通讯作者：
KUNCL, RW