Metal-free intramolecular aminofluorination of alkenes mediated by PhI(OPiv)2/hydrogen fluoride-pyridine system.
Metal-free intramolecular aminofluorination of alkenes mediated by PhI(OPiv)2/hydrogen fluoride-pyridine system.
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DOI：
10.1039/c2ob26664d
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发表时间：
2012-11
影响因子：
3.2
通讯作者：
Qing Wang;W. Zhong;Xionghui Wei;Maoheng Ning;Xiangbao Meng;Zhong-Jun Li
中科院分区：
文献类型：
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作者：
Qing Wang;W. Zhong;Xionghui Wei;Maoheng Ning;Xiangbao Meng;Zhong-Jun Li
本文报道了一种简便的、不含金属的烯烃分子内胺化反应。在BF（3）·OEt（2）存在下，利用易得的PhI（OPiv）（2）和氟化氢-吡啶，对甲苯磺酰基保护的N-4-烯-1-胺一步合成3-F-哌啶，收率高，立体选择性好。
A convenient, metal-free intramolecular aminofluorination of alkenes has been developed. Employing readily available PhI(OPiv)(2) and hydrogen fluoride-pyridine in the presence of BF(3)·OEt(2), tosyl-protected pent-4-en-1-amines were converted to 3-F-piperidines in one step in good yields as well as high stereoselectivity.