Lipid-soluble toxins thought to be specific for Na+ channels block Ca2+ channels in neuronal cells
Lipid-soluble toxins thought to be specific for Na+ channels block Ca2+ channels in neuronal cells
复制标题
脂溶性毒素被认为对 Na 通道具有特异性，可阻断神经元细胞中的 Ca2 通道
DOI：
10.1038/297079a0
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发表时间：
1982
期刊：
影响因子：
64.8
通讯作者：
M. Lazdunski
中科院分区：
文献类型：
--
作者：
G. Romey;M. Lazdunski
许多有毒化合物特别地改变了快速钠电导的功能，该电导负责在神经元和肌肉细胞中产生动作电位。其中一类重要的化合物由脂溶毒素组成，如藜芦碱和其他草珊瑚生物碱、蝙蝠葛毒素、乌头碱和二萜类灰霉毒素。这些分子被认为与Na+通道1-5上的一个共同受体结合，从而引起膜去极化，这种去极化可以被河豚毒素(TTX)或从孵育介质3中去除Na+所抑制。我们在这里表明，这个分子家族不是神经母细胞瘤细胞中的Na+通道所特有的。在分子作用于Na+通道的毒素浓度范围内(藜芦碱、灰毒素)或更低浓度(巴曲霉毒素)，也观察到电压依赖性钙通道的阻断。
Many toxic compounds alter specifically the functioning of the fast sodium conductance that is responsible for the generation of action potentials in neuronal and muscle cells. One important class of these compounds consists of the lipid-soluble toxins, such as veratridine and other ceveratrum alkaloids, batrachotoxin, aconitine, and the diterpenoid grayanotoxins. These molecules are thought to bind to a common receptor site on the Na+ channel1–5, thus inducing a membrane depolarization which can be suppressed by the addition of tetrodotoxin (TTX) or by the removal of Na+ from the incubation medium3. We show here that this family of molecules is not specific for the Na+ channel in neuroblastoma cells. Blockade of the voltage-dependent calcium channel is also observed, either in the toxin concentration range in which the molecules act on the Na+ channel (veratridine, grayanotoxin) or at even lower concentration (batrachotoxin).