Transcriptional Repression by Histone Deacetylases in Plants
Transcriptional Repression by Histone Deacetylases in Plants
复制标题
植物中组蛋白脱乙酰酶的转录抑制
DOI：
10.1093/mp/ssu033
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发表时间：
2014-05-01
期刊：
影响因子：
27.5
通讯作者：
Wu, Keqiang
中科院分区：
文献类型：
--
作者：
Liu, Xuncheng;Yang, Songguang;Wu, Keqiang
组蛋白尾部n端可逆乙酰化和去乙酰化在真核生物基因活性调控中起着至关重要的作用。核心组蛋白的乙酰化通常诱导“开放”染色质结构并与基因激活相关，而组蛋白的去乙酰化通常与“封闭”染色质和基因抑制相关。组蛋白去乙酰化由组蛋白去乙酰化酶（HDACs）催化。越来越多的研究证明了组蛋白去乙酰化/乙酰化对植物基因组稳定性、转录调控和发育的重要性。此外，hdac被证明与多种染色质重塑因子和转录因子相互作用，参与多种发育过程的转录抑制。本文就植物中HDACs介导的转录抑制研究进展进行综述。
Reversible histone acetylation and deacetylation at the N-terminus of histone tails play crucial roles in regulation of eukaryotic gene activity. Acetylation of core histones usually induces an 'open' chromatin structure and is associated with gene activation, whereas deacetylation of histone is often correlated with 'closed' chromatin and gene repression. Histone deacetylation is catalyzed by histone deacetylases (HDACs). A growing number of studies have demonstrated the importance of histone deacetylation/acetylation on genome stability, transcriptional regulation, and development in plants. Furthermore, HDACs were shown to interact with various chromatin remolding factors and transcription factors involved in transcriptional repression in multiple developmental processes. In this review, we summarized recent findings on the transcriptional repression mediated by HDACs in plants.