Exacerbations of chronic obstructive pulmonary disease.
Exacerbations of chronic obstructive pulmonary disease.
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DOI：
10.1513/pats.200701-003fm
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发表时间：
2007-10-01
期刊：
影响因子：
--
通讯作者：
Martinez, Fernando J
中科院分区：
文献类型：
--
作者：
Anzueto, Antonio;Sethi, Sanjay;Martinez, Fernando J
慢性阻塞性肺疾病（COPD）急性加重（AE）的诊断和治疗存在争议。在本节中，我们回顾（1）这种情况的流行病学； (2) 病因——许多 AECOPD 患者被认为同时患有病毒和细菌感染，这导致病情恶化。慢性阻塞性肺病患者在病毒感染后更容易分离出细菌。细菌感染在 AECOPD 中所起的作用仍然是一个非常有争议的话题。 (3) 诊断程序的使用； (4)抗生素的疗效； (5) 用于对患者严重程度进行分层的临床参数； (6) 可以使用的不同类别的抗生素； (7) 其他疗法，包括支气管扩张剂。我们总结了当前的文献，特别强调评估这种情况的长期影响。
The diagnosis and treatment of acute exacerbations (AEs) of chronic obstructive pulmonary disease (COPD) is controversial. In this section, we review (1) the epidemiology of this condition; (2) the etiology--many patients with AECOPD are thought to have a combination of viral and bacterial infections, which contribute to their exacerbation. Bacterial organisms are isolated more commonly after viral infections in patients with COPD. The role that bacterial infections play in AECOPD remains a very controversial topic; (3) the use of diagnostic procedures; (4) efficacy of antibiotics; (5) clinical parameters to stratify patients' severity; (6) different groups of antibiotics that can be used; and (7) other therapies, including bronchodilators. We summarize the current literature, with special emphasis on the assessment of the long-term impact of this condition.