EARLY POLYAMINE TREATMENT ACCELERATES REGENERATION OF RAT SYMPATHETIC NEURONS
EARLY POLYAMINE TREATMENT ACCELERATES REGENERATION OF RAT SYMPATHETIC NEURONS
复制标题
DOI：
10.1016/0014-4886(86)90307-9
复制
发表时间：
1986-06-01
影响因子：
5.3
通讯作者：
GILAD, GM
中科院分区：
文献类型：
--
作者：
DORNAY, M;GILAD, VH;GILAD, GM
轴突损伤后，受损的神经元将其代谢活动转变为旨在生存和再生的修复模式，或者经历变性并死亡。以往的报道表明，在轴突损伤反应的初始阶段，多胺对神经元的存活是必不可少的，可以加速功能恢复。在这项研究中，我们研究了外源性多胺的能力，以加速再生挤压后的节前或节后交感神经的上级颈神经节在成年大鼠。我们发现，早期治疗多胺后，节前或节后神经压榨，加速再现的胆碱乙酰转移酶活性的上级颈神经节，和[3H]去甲肾上腺素摄取的虹膜，分别。眼睑下垂的功能恢复也加快了。我们的结论是，治疗与多胺可以增强周围交感神经元的再生。
After injury of their axons, damaged neurons shift their metabolic activity into a reparative mode aimed at survival and regeneration or, alternatively, they undergo degeneration and die. Previous reports have shown that at the initial stages of the response to axonal injury, polyamines are essential for neuronal survival and can accelerate functional recovery. In this study we examined the ability of exogenous polyamines to accelerate regeneration following crush of the pre- or postganglionic sympathetic nerves of the superior cervical ganglion in adult rats. We found that early treatment with polyamines after pre- or postganglionic nerve crush, accelerated the reappearance of choline acetyltransferase activity in the superior cervical ganglion, and of [3H]norepinephrine uptake in the iris, respectively. Functional recovery from eyelid ptosis was also accelerated. We conclude that treatment with polyamines can enhance regeneration of peripheral sympathetic neurons.