POLYGAMMAGLUTAMYL METABOLITES OF METHOTREXATE
POLYGAMMAGLUTAMYL METABOLITES OF METHOTREXATE
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DOI：
10.1016/0006-291x(73)90949-2
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发表时间：
1973-01-01
影响因子：
3.1
通讯作者：
NAIR, MG
中科院分区：
文献类型：
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作者：
BAUGH, CM;KRUMDIECK, CL;NAIR, MG
迄今为止，甲氨蝶呤(MTX)的未知代谢物已在人的红细胞中被检测到，并从大鼠的肝脏和内脏中分离出来。通过与合成化合物的比较，确定了其代谢产物为2，4-diamino-N10-methylpteroylglutamyl-γ-glutamic酸[2，4-diamino-N10-methylpteroylglutamyl-γ-glutamyl-γ-glutamic(G1)]和MTX酸(G2)。
Heretofore unrecognized metabolites of methotrexate (MTX) have been detected in human red blood cells and isolated from rat liver and viscera. The metabolites from the rat were identified as 2,4-diamino-N10-methylpteroylglutamyl-γ-glutamic acid [MTX(G1)] and 2,4-diamino-N10-methylpteroylglutamyl-γ-glutamyl-γ-glutamic acid [MTX(G2)] by comparison with authentic synthetic compounds.