Lateralization of the human mirror neuron system
Lateralization of the human mirror neuron system
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DOI：
10.1523/jneurosci.2921-05.2006
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发表时间：
2006-03-15
影响因子：
5.3
通讯作者：
Iacoboni, M
中科院分区：
文献类型：
--
作者：
Aziz-Zadeh, L;Koski, L;Iacoboni, M
一个由下额叶、喙侧下顶叶和后上级颞叶皮质组成的皮质网络与灵长类大脑中的行为表征有关，对人类的模仿至关重要。这种神经回路可能是与语言相关的神经系统的进化先驱。然而，语言主要偏向左半球，而人类模仿回路的偏侧化程度尚不清楚。我们进行了一项功能磁共振成像研究的模仿手指运动与偏侧刺激和反应。在模仿过程中，下额叶和喙下顶叶皮层的活动，虽然相当双边，是在同侧的视觉刺激和反应的手半球更强。这种同侧模式与主要视觉和运动区的典型对侧活动不同。左侧和右侧模仿任务均观察到右侧上级颞沟（STS）信号可靠增加，但在左侧STS中也观察到阈下活动。总的来说，数据表明，视觉和运动组件的人类镜像系统不左侧化。那么，左脑在语言方面的优势一定受到了其他类型的语言前体的青睐，可能是听觉或多模态动作表征。
A cortical network consisting of the inferior frontal, rostral inferior parietal, and posterior superior temporal cortices has been implicated in representing actions in the primate brain and is critical to imitation in humans. This neural circuitry may be an evolutionary precursor of neural systems associated with language. However, language is predominantly lateralized to the left hemisphere, whereas the degree of lateralization of the imitation circuitry in humans is unclear. We conducted a functional magnetic resonance imaging study of imitation of finger movements with lateralized stimuli and responses. During imitation, activity in the inferior frontal and rostral inferior parietal cortex, although fairly bilateral, was stronger in the hemisphere ipsilateral to the visual stimulus and response hand. This ipsilateral pattern is at variance with the typical contralateral activity of primary visual and motor areas. Reliably increased signal in the right superior temporal sulcus (STS) was observed for both left-sided and right-sided imitation tasks, although subthreshold activity was also observed in the left STS. Overall, the data indicate that visual and motor components of the human mirror system are not left-lateralized. The left hemisphere superiority for language, then, must be have been favored by other types of language precursors, perhaps auditory or multimodal action representations.