Optimizing signal intensity correction during evaluation of hepatic parenchymal enhancement on gadoxetate disodium-enhanced MRI: Comparison of three methods
Optimizing signal intensity correction during evaluation of hepatic parenchymal enhancement on gadoxetate disodium-enhanced MRI: Comparison of three methods
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DOI：
10.1016/j.ejrad.2014.11.014
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发表时间：
2015-03-01
影响因子：
3.3
通讯作者：
Miyati, Tosiaki
中科院分区：
文献类型：
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作者：
Onoda, Minori;Hyodo, Tomoko;Miyati, Tosiaki
目的：比较Gd-EOB-DTPA肝脏多期增强信号强度(SI)的尺度和重标斜率校正与脾和肌肉SIS信号强度校正，并与Look-Locker Turbo-field-ECHER序列(ER-T-1)的T1值进行相关性。材料与方法：对30例患者行Gd-EOB-DTPA增强磁共振成像(MRI)。分别于注射Gd-EOB-DTPA前、注射Gd-EOB-DTPA后2(第一相)、10(第二相)和20min(第三相)采集屏气T1加权脂肪抑制三维(3D)梯度回波序列(e-Thrive)。分别在增强前和增强后1.5(第一期)、8(第二期)和18min(第三期)采集Look-Locker Turbo-Fieldecho(LL-TFE)序列。分别使用e-Thrive序列的信号强度(ER-SI)和由LL-TFE序列数据产生的T-1值(ER-T-1)计算各期的肝实质增强率(ER)。ER-SIS的计算方法有三种：(1)与脾SI(ER-SI-S)比较，(2)与肌肉SI(ER-SI-m)比较，(3)使用DICOM头的尺度和重定标斜率(ER-SI-c)来消除接收器增益和尺度的影响。结果：在第一阶段，ER-SI与ER-T-1的相关性和一致性均较弱。在第二和第三阶段，ER-SI-c与ER-Ti呈较强的线性相关(r(2)=0.71-0.72，p
Objective: To compare signal intensity (SI) correction using scale and rescale slopes with SI correction using SIs of spleen and muscle for quantifying multiphase hepatic contrast enhancement with Gd-EOB-DTPA by assessing their correlation with T-1 values generated from Look-Locker turbo-field-echo (LL-TFE) sequence data (ER-T-1).Materials and methods: Thirty patients underwent Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) in this prospective clinical study. For each patient, breath-hold T-1-weighted fat-suppressed three-dimensional (3D) gradient echo sequences (e-THRIVE) were acquired before and 2 (first phase), 10 (second phase), and 20 min (third phase) after intravenous Gd-EOB-DTPA. Look-Locker turbo-fieldecho (LL-TFE) sequences were acquired before and 1.5 (first phase), 8 (second phase), and 18 min (third phase) postcontrast. The liver parenchyma enhancement ratios (ER) of each phase were calculated using the SI from e-THRIVE sequences (ER-SI) and the T-1 values generated from LL-TFE sequence data (ER-T-1) respectively. ER-SIs were calculated in three ways: (1) comparing with splenic SI (ER-SI-s), (2) comparing with muscle SI (ER-SI-m), (3) using scale and rescale slopes obtained from DICOM headers (ER-SI-c), to eliminate the effects of receiver gain and scaling. For each of the first, second and third phases, correlation and agreement were assessed between each ER-SI and ER-T-1.Results: In the first phase, all ER-SIs correlated weakly with ER-Ti. In the second and third phases, ER-SI-c showed a stronger linear correlation with ER-Ti (r(2) =0.71-0.72, p