Association of ALOX12 and ALOX15 gene polymorphisms with age at menarche and natural menopause in Chinese women
Association of ALOX12 and ALOX15 gene polymorphisms with age at menarche and natural menopause in Chinese women
复制标题
DOI：
10.1097/gme.0b013e31824e6160
复制
发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
W. Xiao;Yao-hua Ke;Jin-wei He;Hao Zhang;Jin-bo Yu;Wei-wei Hu;J. Gu;H. Yue;Chun Wang;Yunqiu Hu;Miao Li;W. Fu;Yujuan Liu;Zhenlin Zhang
中科院分区：
文献类型：
--
作者：
W. Xiao;Yao-hua Ke;Jin-wei He;Hao Zhang;Jin-bo Yu;Wei-wei Hu;J. Gu;H. Yue;Chun Wang;Yunqiu Hu;Miao Li;W. Fu;Yujuan Liu;Zhenlin Zhang
Objective Lipoxygenase (LOX) is one of the major metabolic enzymes for arachidonic acid, which has been reported to be associated with many postmenopausal and many hormone-related diseases. In rats, selective inhibition of the LOX pathway led to defective ovulation. However, little is known about the association of the LOX-related genes with menstruation in women. In this study, we investigated the possible association of two key gene (ALOX12 and ALOX15) polymorphisms with age of menarche and menopause in Chinese women. Methods Six tagging single nucleotide polymorphisms (SNPs) of ALOX12 and five SNPs of ALOX15 were genotyped. The association of single SNPs and haplotypes in two candidate genes and age at menarche (AAM) variation was tested in 401 Chinese nuclear families using the quantitative transmissing disequilibrium test. Furthermore, the association between these SNPs and haplotypes and age at natural menopause (AANM) in 710 postmenopausal Chinese women was measured. Results Using family- and population-based statistical procedures, significant association was found between SNPs rs312462 in ALOX12 and AAM in nuclear families (P = 0.043), and three SNPs (rs2292350, rs312470, and rs312462) in ALOX12 were significantly associated with AANM in postmenopausal women (P = 0.012, P = 0.045, and P = 0.033, respectively). Haplotype analyses corroborated our single SNP results (P = 0.030). However, we failed to find a significant association between ALOX15 gene polymorphisms and AAM as well as AANM (P > 0.05). Conclusions Our present results suggest that genetic variations in ALOX12 are associated with both the onset and cessation of menstruation in Chinese women living in Shanghai.
