Total Serum Immunoglobulin E in Children with Asthma
Total Serum Immunoglobulin E in Children with Asthma
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DOI：
10.1007/s12291-012-0247-2
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发表时间：
2013-04-01
影响因子：
2.1
通讯作者：
Chaudhuri, T. K.
中科院分区：
文献类型：
--
作者：
Lama, M.;Chatterjee, M.;Chaudhuri, T. K.
免疫球蛋白 (Ig) E 已被证明是哮喘支气管高反应性发生的主要因素。血清 IgE 水平升高会导致哮喘，并被认为是哮喘发生的有效预测因子。本研究的目的是估计哮喘患者和健康对照受试者的血清总 IgE 水平，并研究哮喘患者的各种人口和临床特征与血清总 IgE 水平的关系。我们使用 ELISA 试剂盒（AccuBind，Monobind Inc.，美国）测量血清总 IgE 水平。使用问卷获得相关的人口统计学和临床数据。结果显示，与健康对照相比，哮喘儿童血清总IgE水平显着升高。 44例哮喘患儿血清中总IgE与IL-4水平呈显着正相关。研究发现，哮喘儿童血清总 IgE >150 IU/mL 与年龄、吸烟暴露和嗜酸性粒细胞计数升高显着相关。总之，血清总 IgE 水平升高可能表明研究对象存在哮喘的过敏病因。
Immunoglobulin (Ig) E has been shown to be a major contributing factor for the development of bronchial hyperresponsiveness in asthma. An elevation in serum IgE levels contributes to asthma and is considered a potent predictor of the development of asthma. The objectives of the present study were to estimate the levels of total serum IgE in asthmatic and healthy control subjects and to investigate the relationship of various demographic and clinical characteristics with the total serum IgE level in asthmatics. We measured the levels of total serum IgE using the ELISA kits (AccuBind, Monobind Inc., USA). The relevant demographic and clinical data were obtained using the questionnaire. The results showed that asthmatic children had significantly elevated level of total serum IgE compared to that of the healthy controls. The levels of total IgE and IL-4 in sera of 44 asthmatic children showed a significant positive correlation. Total serum IgE >150 IU/mL was found to be significantly associated with the age, exposure to cigarette smoke, and raised eosinophil count in asthmatic children. In conclusion, the elevated level of total serum IgE may demonstrate the allergic etiology of asthma in the subjects studied.