Large-scale chronically implantable precision motorized microdrive array for freely behaving animals
Large-scale chronically implantable precision motorized microdrive array for freely behaving animals
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DOI：
10.1152/jn.90687.2008
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发表时间：
2008-10-01
影响因子：
2.5
通讯作者：
Wilson, Matthew A.
中科院分区：
文献类型：
--
作者：
Yamamoto, Jun;Wilson, Matthew A.
多个单单位记录已成为研究神经回路的最强大的体内电生理技术之一。对小型和轻型慢性记录设备的需求一直在增加，这些设备允许在多个大脑区域的大量电极上进行精细调整。为了实现这一目标，我们开发了精密电动微驱动器阵列，使用一种新型的电机多路复用头台，以显着减少布线，同时保持微驱动器控制的精度。将微驱动器阵列的版本长期植入大鼠（21个微驱动器）和小鼠（7个微驱动器），并进行相对长期的记录。
Multiple single-unit recording has become one of the most powerful in vivo electro-physiological techniques for studying neural circuits. The demand has been increasing for small and lightweight chronic recording devices that allow fine adjustments to be made over large numbers of electrodes across multiple brain regions. To achieve this, we developed precision motorized microdrive arrays that use a novel motor multiplexing headstage to dramatically reduce wiring while preserving precision of the microdrive control. Versions of the microdrive array were chronically implanted on both rats (21 microdrives) and mice (7 microdrives), and relatively long-term recordings were taken.