The excess of atopic eczema in East Germany is related to the intrinsic type
The excess of atopic eczema in East Germany is related to the intrinsic type
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DOI：
10.1046/j.1365-2133.2000.03832.x
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发表时间：
2000-11-01
影响因子：
10.3
通讯作者：
Ring, J
中科院分区：
文献类型：
--
作者：
Schäfer, T;Krämer, U;Ring, J
背景：迄今为止，在德国东部和西部，基于皮肤病学检查的特应性湿疹患病率数据尚不可用。可能的差异的比例的外在和内在类型的湿疹，以及多远，这些可以解释湿疹的患病率差异，需要澄清。目的比较特应性湿疹的患病率在学龄前儿童之间的不同地点在东部和西部德国，并在一段时间内的7年，在三个时间点。此外，以确定湿疹的内在和外在类型的比例，采取皮肤点刺试验reactivityingaccount.Methods重复横断面研究在1991年，1994年和1997年在5-6岁的学龄前儿童在5个不同的地点在西德国（n = 2075）和6个在东德国（n = 1926）进行了。湿疹患者由皮肤科医生进行检查确定。此外，皮肤点刺试验和一个标准化的questionnaire used.Results过敏性湿疹的总患病率在这些孩子是10.4%。在所有三次调查中（1991年，17.5% vs. 11.2%; 1994年，12.6% vs. 8.7%; 1997年，11.2% vs. 4.5%）和总组中（12.9% vs. 8.2%），东德的患病率显著高于西德（德国）。在多元逻辑回归分析中控制了性别、父母特应性疾病史、观察者和社会经济地位的影响后，这些差异在1991年、1994年和整个组中仍然具有显著性（比值比，OR 1.78，95%置信区间，CI 1.43-2.21）。女孩（OR 1.56，95%CI 1.27-1.92）和父母受教育程度较高的儿童（OR 1.17，95%CI 1.00-1.37）更容易受到影响。在所有儿童中，26.6%和湿疹儿童中，41.9%在点刺试验中表现出至少一种反应（OR 2.21，95% CI 1.75-2.80;湿疹致敏vs.无湿疹）。而在德国西部，50.4%的湿疹儿童过敏，而在德国东部，只有36.5%的患病儿童在点刺试验中呈阳性反应（OR 1.77，95% CI 1.12-2.79）结论这些结果与有关过敏性致敏和花粉热的研究结果一致，并可能表明过敏以外的因素是导致花粉热患病率较高的原因。特应性湿疹在东德国。
Background Prevalence data for atopic eczema based on a dermatological examination have not so far been available for East and West Germany. Possible differences in the proportions of extrinsic and intrinsic types of eczema, and how far these could explain differences in the prevalence of eczema, need to be clarified.Objectives To compare the prevalence of atopic eczema in pre-school children between different locations in East and West Germany, and over a period of 7 years, at three time points. Additionally, to determine the proportions of intrinsic and extrinsic types of eczema by taking skin prick test reactivity into account.Methods Repeated cross-sectional studies in 1991, 1994 and 1997 in 5-6-year-old pre-school children at five different locations in West Germany (n = 2075) and six in East Germany (n = 1926) were carried out. Individuals with eczema were identified by an examination performed by physicians of the Department of Dermatology. In addition, a skin prick test and a standardized questionnaire were used.Results The overall prevalence of atopic eczema in these children was 10.4%. At all three times of investigation (1991, 17.5% vs. 11.2%; 1994, 12.6% vs. 8.7%; 1997, 11.2% vs. 4.5%) and in the total group (12.9% vs. 8.2%), the prevalence was significantly higher in East than in West Germany. After controlling for influences of sex, parental history of atopic diseases, observer and socio-economic status in multiple logistic regression analyses, these differences remained significant for 1991, 1994 and for the overall group (odds ratio, OR 1.78, 95% confidence interval, CI 1.43-2.21). Girls (OR 1.56, 95% CI 1.27-1.92) and children whose parents had a higher level of school education (OR 1.17, 95% CI 1.00-1.37) were affected more frequently. Of all children, 26.6%, and of those with eczema, 41.9% exhibited at least one reaction in the prick test (OR 2.21, 95% CI 1.75-2.80; sensitization in eczema vs. no eczema). Whereas 50.4% of the children with eczema in West Germany were sensitized, only 36.5% of the diseased children in East Germany reacted positively in the prick test (OR 1.77, 95% CI 1.12-2.79).Conclusions These results are in accordance with findings regarding allergic sensitization and hay fever and might indicate that factors other than allergy are responsible for the higher prevalence of atopic eczema in East Germany.